Vécsei L, Bollók I, Telegdy G, Schally A V
Pharmacol Res Commun. 1984 Jul;16(7):689-97. doi: 10.1016/s0031-6989(84)80047-8.
The effect of beta-(Tyr9)melanotropin-(9-18) and amphetamine on the open-field behavior and the striatal dopamine uptake and release were compared. beta-(Tyr9)melanotropin-(9-18) at doses of 1 microgram (icv) or 2 micrograms (icv) increased the ambulation of the rats, while in a dose of 5 micrograms (icv), it had no effect. Amphetamine had a similar dose-related effect on ambulation. This peptide also increased the rearing activity, in doses of 2 micrograms or 5 micrograms (icv), while amphetamine was effective only in a dose of 2 micrograms (icv). beta-(Tyr9)melanotropin-(9-18) at doses of 1 microgram, 2 micrograms or 5 micrograms (icv) increased the grooming, while amphetamine at the same doses decrease it. The peptide had no significant influence on the striatal dopamine uptake and release, whereas amphetamine markedly decreased the uptake and facilitated the release in a dose-related manner. These results suggest that although beta-(Tyr9)melanotropin-(9-18) and amphetamine have similar effects on the open-field behavior, the mechanisms of action of the two substances are different.
比较了β -（酪氨酰9）促黑素 -（9 - 18）和苯丙胺对旷场行为以及纹状体多巴胺摄取和释放的影响。剂量为1微克（脑室内注射）或2微克（脑室内注射）的β -（酪氨酰9）促黑素 -（9 - 18）可增加大鼠的行走活动，而剂量为5微克（脑室内注射）时则无此作用。苯丙胺对行走活动有类似的剂量相关效应。该肽在剂量为2微克或5微克（脑室内注射）时也可增加竖毛活动，而苯丙胺仅在剂量为2微克（脑室内注射）时有效。剂量为1微克、2微克或5微克（脑室内注射）的β -（酪氨酰9）促黑素 -（9 - 18）可增加理毛行为，而相同剂量的苯丙胺则使其减少。该肽对纹状体多巴胺的摄取和释放无显著影响，而苯丙胺则以剂量相关的方式显著降低摄取并促进释放。这些结果表明，尽管β -（酪氨酰9）促黑素 -（9 - 18）和苯丙胺对旷场行为有类似影响，但这两种物质的作用机制不同。
