Vécsei L, Bollók I, Telegdy G, Coy D H, Schally A V
Pharmacol Res Commun. 1984 Apr;16(4):369-79. doi: 10.1016/s0031-6989(84)80005-3.
beta-(Tyr9)melanotropin-(9-18) inhibited the extinction of active avoidance behavior. The muscarinic cholinergic blocker atropine did not influence the peptide-induced inhibition, whereas the beta-receptor blocker propranolol decreased it. Furthermore, the peptide increased the ambulation of the animals. Neither the muscarinic blocker nor the beta-blocker had any action on this effect of beta-(Tyr9)melanotropin-(9-18). Atropine markedly decreased the defecation of the animals, and this effect was not influenced by the peptide. The results suggest that the beta-receptors play an important role in the inhibition of extinction induced by the peptide, however, the actions on the open-field activity are mediated by different mechanisms.
β-（酪氨酰9）促黑素-（9-18）抑制主动回避行为的消退。毒蕈碱型胆碱能阻滞剂阿托品不影响该肽诱导的抑制作用，而β受体阻滞剂普萘洛尔则降低这种抑制作用。此外，该肽增加了动物的走动。毒蕈碱阻滞剂和β阻滞剂对β-（酪氨酰9）促黑素-（9-18）的这种作用均无影响。阿托品显著减少动物的排便，且该作用不受该肽的影响。结果表明，β受体在该肽诱导的消退抑制中起重要作用，然而，对旷场活动的作用是由不同机制介导的。
