Agnew J E, Pavia D, Clarke S W
Phys Med Biol. 1984 Jul;29(7):767-77. doi: 10.1088/0031-9155/29/7/001.
Modelling of inhaled particle deposition in the lungs potentially offers data relevant to assessing hazards from toxic inhaled particles, to studying mucus clearance or lung permeability by aerosol techniques, and to achieving better utilisation of drugs administered as aerosols. Analysis of published modelling studies is complicated by differing approaches to the quantitative estimation of physical factors determining deposition and by differing choices of anatomical data. Published formulae for predicting aerosol particle impaction are compared by applying them to the deposition of 5 micron particles in the human conducting airways using the morphological data of Weibel together with information from other sources about airways branching angles. The results indicate the range of deposition estimates that may be obtained from currently available impaction formulae. All but one of the formulae considered agree in indicating maximum deposition by impaction in, or close to, the segmental or subsegmental bronchi. Data are presented to indicate how the principal physical determinants of deposition depend on particle size, inhalation flow rate and lung volume during inhalation.
肺部吸入颗粒沉积的建模有可能提供与评估有毒吸入颗粒的危害、通过气溶胶技术研究黏液清除或肺通透性以及更好地利用气溶胶给药的药物相关的数据。已发表的建模研究分析因确定沉积的物理因素的定量估计方法不同以及解剖学数据的选择不同而变得复杂。通过将预测气溶胶颗粒撞击的已发表公式应用于使用韦贝尔形态学数据以及来自其他来源的气道分支角度信息的人类传导气道中5微米颗粒的沉积，对这些公式进行了比较。结果表明了从当前可用的撞击公式可能获得的沉积估计范围。所考虑的公式中除一个之外，其他所有公式都一致表明在段或亚段支气管内或附近通过撞击实现最大沉积。给出的数据表明沉积的主要物理决定因素如何取决于吸入过程中的颗粒大小、吸入流速和肺容积。
