Caniggia A, Gennari C, Vattimo A, Runci F, Bombardieri S
Calcif Tissue Res. 1978 Feb 28;25(1):53-7. doi: 10.1007/BF02010751.
A patient showed evident osteolysis in phalanges and heavy periarticular calcium deposits of the fingers, wrists and toes which avidly took up 47Ca. The dense, white, tooth-paste like fluid contained in the periarticular calcium deposits has been studied by two different X-ray diffraction methods, by Ubatuba's bioassay for prostaglandin, by thin layer chromatography and by mass spectrometry. The calcium deposits were hydroxyapatite and prostaglandin PGE2 was detected in them. The bone resorption stimulating activity of PGE2 would be expected to result in increased bone destruction with release of calcium salts and this could be a working hypothesis of the pathogenesis of calcinosis circumscripta.
一名患者的指骨出现明显骨质溶解，手指、手腕和脚趾关节周围有大量钙沉积，这些钙沉积能大量摄取47Ca。已通过两种不同的X射线衍射方法、乌巴图巴前列腺素生物测定法、薄层色谱法和质谱法对关节周围钙沉积中所含的致密、白色、牙膏状液体进行了研究。钙沉积为羟基磷灰石，且在其中检测到了前列腺素PGE2。预计PGE2的骨吸收刺激活性会导致骨破坏增加并伴有钙盐释放，这可能是局限性钙质沉着症发病机制的一个可行假设。
