Goluboff N, Cram R, Ramgotra B, Singh A, Wilkinson G W
Can Med Assoc J. 1978 Apr 22;118(8):924-8.
The association of bone lesions, polyarthritis and cutaneous nodules with pancreatic disease is being recognized and reported more frequently. In adults all forms of pancreatitis and carcinoma of the pancreas have been involved, but in the few children described these complications have been associated with acute traumatic pancreatitis. This paper describes two cases of acute traumatic pancreatitis in which polyarthritis and limb pains were noted after 2 to 3 weeks. In one child osteolytic lesions and periostitis were seen on roentgenograms 7 weeks after the onset of pancreatitis. In the other child minor roentgenographic changes were not seen until 5 months after the onset; however, bone scans showed clear-cut abnormalities after 1 month. Almost complete resolution could be expected within a year. Serum lipase and amylase concentrations remained elevated during the acute illness. Disseminated fat necrosis is apparently related to the excess amounts of circulating lipase.
骨病变、多关节炎和皮肤结节与胰腺疾病之间的关联正越来越频繁地得到认识和报道。在成人中,各种形式的胰腺炎和胰腺癌均有涉及,但在已描述的少数儿童病例中,这些并发症与急性创伤性胰腺炎有关。本文描述了两例急性创伤性胰腺炎病例,其中在2至3周后出现了多关节炎和肢体疼痛。在一名儿童中,胰腺炎发作7周后,X线片显示有溶骨性病变和骨膜炎。在另一名儿童中,直到发作5个月后才出现轻微的X线变化;然而,骨扫描在1个月后显示出明确的异常。预计一年内几乎可完全恢复。急性发病期间血清脂肪酶和淀粉酶浓度持续升高。播散性脂肪坏死显然与循环中脂肪酶的过量有关。