Khaw K T, Barrett-Connor E
Am J Epidemiol. 1984 Oct;120(4):550-8. doi: 10.1093/oxfordjournals.aje.a113916.
In a nine-year follow-up of a southern California community of 2,852 men and women aged 60-79 years, systolic blood pressure was a significant predictor of subsequent cancer mortality in men. This effect was independent of age, antihypertensive medication, smoking, obesity, and plasma cholesterol. Trends in women were similar but not statistically significant. Compared with those still alive, higher initial systolic blood pressure levels were apparent in those who died of colon cancer, stomach cancer, and all other cancers combined except for lung and prostate cancer. Possible mechanisms for this association and the implications of the data with regard to the benefits of measures to treat high blood pressure or lower population distribution of blood pressure are discussed.
在对南加州一个由2852名年龄在60至79岁之间的男性和女性组成的社区进行的九年随访中，收缩压是男性后续癌症死亡率的一个重要预测指标。这种影响独立于年龄、抗高血压药物、吸烟、肥胖和血浆胆固醇。女性的趋势相似但无统计学意义。与仍在世者相比，死于结肠癌、胃癌以及除肺癌和前列腺癌之外的所有其他癌症组合的人群，其初始收缩压水平更高。本文讨论了这种关联的可能机制以及这些数据对于治疗高血压措施的益处或降低人群血压分布的意义。
