Peleg I, Morris S, Hames C G
Med Oncol Tumor Pharmacother. 1985;2(3):157-63. doi: 10.1007/BF02934543.
A narrow band of counties extending along the southeastern Atlantic coast from Jacksonville, Florida to Charleston, South Carolina were found to have excessively high incidence rates for esophageal cancer in non-white males. White males in the same areas have a 30% higher incidence rate for lung cancer but only average incidence rates were found for non-white males. Selenium is considered to decrease cancer risk in the animal model. In this coastal region, a study of 130 cancer patients who developed a malignancy 2-12 years after baseline examination showed no dose response relationship between baseline serum selenium levels and risk of subsequent cancer.
人们发现，从佛罗里达州杰克逊维尔到南卡罗来纳州查尔斯顿沿东南大西洋海岸延伸的狭长地带的县，非白人男性的食管癌发病率过高。同一地区的白人男性肺癌发病率高出30%，但非白人男性仅为平均发病率。在动物模型中，硒被认为可降低癌症风险。在这个沿海地区，一项对130名癌症患者的研究发现，这些患者在基线检查后2至12年患上恶性肿瘤，其基线血清硒水平与后续癌症风险之间不存在剂量反应关系。
