Mason P R, Tswana S A
Am J Trop Med Hyg. 1984 Jul;33(4):599-601. doi: 10.4269/ajtmh.1984.33.599.
The excretion of Schistosoma haematobium eggs by school children in an endemic area of Zimbabwe was studied for 16 weeks following a single oral dose of 10 mg/kg body weight metrifonate. By 16 weeks, 40.7% of the children had ceased excreting eggs. The mean reduction in egg excretion was 75.1%, but over half the children showed a greater than 90% reduction. Of the treatment failures, the majority showed less marked or transient reductions in egg excretion, though evidence suggested that 17.5% of the failures may have been due to reinfection.
