Månsson P E, Pero R W, Brandt L
Cancer Lett. 1978 Feb;4(2):99-107. doi: 10.1016/s0304-3835(78)93742-4.
Tritium labelled heterogeneous nuclear RNA (HnRNA) from normal and chronic lymphocytic leukemic (CLL) lymphocytes was investigated before and after fractionation into non-poly(A) containing (-HnRNA) and poly(A) containing (+HnRNA) HnRNA with respect to double stranded RNA (dsRNA). Statistically significant higher amounts of rapidly labelled RNA were recovered from CLL lymphocytes when compared to normal cases. Within the CLL cases a significant linear correlation (r = 0.95) was found between white blood cell counts and the amount of dsRNA in total HnRNA. After fractionation into (-) and (+) HnRNAs the ratios of dsRNAs, expressed as the dsRNA in (-) HnRNA divided by the dsRNA in (+) HnRNA, was lower than the corresponding values in normal cases for all the CLL cases except one. The relationship between (+) HnRNA and the total dsRNA level was different when comparing CLL and normal lymphocytes indicating a RNA processing abnormality.
对来自正常淋巴细胞和慢性淋巴细胞白血病（CLL）淋巴细胞的氚标记异质性核RNA（HnRNA）进行了研究，在将其分离为不含多聚腺苷酸（-HnRNA）和含多聚腺苷酸（+HnRNA）的HnRNA之前和之后，检测其双链RNA（dsRNA）情况。与正常病例相比，从CLL淋巴细胞中回收的快速标记RNA量在统计学上显著更高。在CLL病例中，白细胞计数与总HnRNA中dsRNA的量之间存在显著的线性相关性（r = 0.95）。在分离为（-）和（+）HnRNA后，除一例CLL病例外，所有CLL病例中dsRNA的比率（以（-）HnRNA中的dsRNA除以（+）HnRNA中的dsRNA表示）均低于正常病例的相应值。比较CLL淋巴细胞和正常淋巴细胞时，（+）HnRNA与总dsRNA水平之间的关系不同，表明存在RNA加工异常。
