Bornstein W A, Lamden M P, Chuang A H, Gross R L, Newberne P M, Bresnick E
Cancer Res. 1978 Jun;38(6):1497-501.
Syrian golden hamsters were placed on a control or vitamin A-deficient diet. When their serum vitamin A content was significantly reduced, i.e., to less than 10% of controls, the hamsters were killed and lung aryl hydrocarbon hydroxylase activity and metabolism of benzo(a)pyrene were determined. The benzo(a)pyrene metabolite profile was similar with control and A-deficient systems, and only few quantitative differences were noted. Addition of beta-retinyl acetate to the in vitro incubations did not substantially affect benzo(a)pyrene metabolism.
将叙利亚金黄地鼠分为对照组和维生素A缺乏组进行饲养。当它们血清中的维生素A含量显著降低，即降至对照组的10%以下时，处死这些地鼠，并测定其肺芳烃羟化酶活性和苯并(a)芘的代谢情况。对照组和维生素A缺乏组的苯并(a)芘代谢产物谱相似，仅发现少量定量差异。在体外孵育体系中添加β-视黄基乙酸酯对苯并(a)芘的代谢没有实质性影响。
