阿米氟沙星对肠杆菌科外膜突变体的体外活性及自发耐药频率
In vitro activity of amifloxacin against outer membrane mutants of the family Enterobacteriaceae and frequency of spontaneous resistance.
作者信息
Watanabe M, Inoue M, Mitsuhashi S
机构信息
Episome Institute, Seta-gun, Japan.
出版信息
Antimicrob Agents Chemother. 1989 Nov;33(11):1837-40. doi: 10.1128/AAC.33.11.1837.
Abstract
Amifloxacin showed potent inhibitory activity against DNA gyrase of Escherichia coli. The difference in the susceptibilities of lipopolysaccharide-deficient Salmonella typhimurium mutants and their parent strain was less than twofold, and the difference in the susceptibilities of porin-deficient E. coli mutants and their parent strain was less than twofold. There was cross resistance among the quinolone group of agents; however, the decrease in MIC for norB mutants was slightly lower than that of other fluoroquinolones. Cell lysis was induced with combined treatment of amifloxacin and sodium dodecyl sulfate in E. coli. The frequency of mutants spontaneously resistant to amifloxacin was extremely low in all species tested.
摘要
阿米氟沙星对大肠杆菌的DNA回旋酶表现出强效抑制活性。脂多糖缺陷型鼠伤寒沙门氏菌突变体与其亲本菌株的敏感性差异小于两倍，孔蛋白缺陷型大肠杆菌突变体与其亲本菌株的敏感性差异小于两倍。喹诺酮类药物之间存在交叉耐药性；然而，norB突变体的最低抑菌浓度（MIC）降低幅度略低于其他氟喹诺酮类药物。在大肠杆菌中，阿米氟沙星与十二烷基硫酸钠联合处理可诱导细胞裂解。在所有测试物种中，对阿米氟沙星自发耐药的突变体频率极低。
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