持续输注豚鼠外淋巴液和血浆中阿米卡星浓度的相关性
Correlation of amikacin concentrations in perilymph and plasma of continuously infused guinea pigs.
作者信息
Desjardins-Giasson S, Beaubien A R
出版信息
Antimicrob Agents Chemother. 1984 Jul;26(1):87-90. doi: 10.1128/AAC.26.1.87.
Abstract
A commercially available radioimmunoassay kit was modified to enable us to measure, in triplicate, the amikacin concentration in 1 microliter of perilymph fluid. Amikacin levels in plasma and perilymph were measured in guinea pigs after continuous intravenous infusion at four different dosing rates. After a 4-h infusion, a good linear correlation was found between the amikacin concentration in plasma and the dosing rate. Likewise, a significant linear relationship was found between concentrations of amikacin in perilymph and plasma (y = 0.21x + 2.56; r = 0.67; n = 45) after 6 h of infusion. These results suggest nonsaturation kinetics at the concentrations used.
摘要
对一种市售的放射免疫分析试剂盒进行了改进，使我们能够对1微升外淋巴液中的阿米卡星浓度进行三次测量。在豚鼠以四种不同给药速率持续静脉输注后，测量血浆和外淋巴中的阿米卡星水平。输注4小时后，血浆中阿米卡星浓度与给药速率之间发现良好的线性相关性。同样，输注6小时后，外淋巴和血浆中阿米卡星浓度之间也发现显著的线性关系（y = 0.21x + 2.56；r = 0.67；n = 45）。这些结果表明在所使用的浓度下存在非饱和动力学。
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本文引用的文献
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