Persson H E, Wanger P
Br J Ophthalmol. 1984 Oct;68(10):760-4. doi: 10.1136/bjo.68.10.760.
Pattern-reversal and flash electroretinograms (ERG) and visual evoked cortical potentials (VECP) were recorded from 15 patients with definite multiple sclerosis (MS). All patients had prolonged VECP latency, indicating demyelination of one or both optic nerves. The pattern-reversal ERG amplitude was reduced below the level of normal variation (mean -2 SD) in 11 of the 22 eyes with prolonged VECP latency and in one of the eight eyes with normal VECP latency. The mean pattern-reversal ERG amplitude from eyes with prolonged VECP latencies was significantly lower than the mean amplitude from the normal controls. No abnormalities were observed in the flash ERGs. Degeneration of retinal ganglion cell axons has been demonstrated in MS patients. The amplitude reduction in the pattern-reversal ERG, observed in some 50% of the eyes with prolonged VECP latencies, is supposed to reflect retinal ganglion cell dysfunction or degeneration secondary to demyelination of the optic nerve.
对15例确诊为多发性硬化症（MS）的患者进行了图形翻转视网膜电图（ERG）、闪光视网膜电图及视觉诱发电位（VECP）检查。所有患者的VECP潜伏期均延长，提示一条或两条视神经发生脱髓鞘病变。在VECP潜伏期延长的22只眼中，有11只眼的图形翻转ERG振幅降低至正常变异范围以下（均值减2个标准差），在VECP潜伏期正常的8只眼中，有1只眼出现这种情况。VECP潜伏期延长的眼睛的图形翻转ERG平均振幅显著低于正常对照组的平均振幅。闪光ERG未观察到异常。已证实MS患者存在视网膜神经节细胞轴突变性。在VECP潜伏期延长的约50%的眼中观察到的图形翻转ERG振幅降低，被认为反映了继发于视神经脱髓鞘的视网膜神经节细胞功能障碍或变性。
