Holmes G L, Thompson J L
Department of Neurology, Medical College of Georgia, Augusta 30912-2366.
Brain Res. 1988 Mar 1;467(1):51-9. doi: 10.1016/0165-3806(88)90066-1.
The short and long-term effects of systemic administration of kainic acid to immature animals were studied in rats. Kainic acid was administered systemically to rats of 1-30 days of age. The rats were monitored for both behavioral and EEG changes. To study the effects of kainic acid on seizure susceptibility, status epilepticus was induced in 12-, 18-, and 27-day-old rats by systemic administration of kainic acid. Seizure susceptibility was assessed 3 days later using the kindling technique. In addition, another group of 27-day-old rats that developed status epilepticus following systemic administration of kainic acid were kindled as adults. Young rats (1 day of age) developed behavioral status epilepticus after kainic acid and ictal electroencephalographic changes were seen beginning at age 6 days. The 15- and 21-day-old rats kindled 3 days after kainic acid administration kindled at the same rate as controls. However, 30-day-old rats that received kainic acid at age 27 days kindled more quickly to stage-5 seizures than controls. Rats that received kainic acid at age 27 days and maintained until adulthood developed spontaneous recurrent seizures and kindled faster as adults than controls. These results demonstrate that the effect of kainic acid on seizure susceptibility is an age-dependent phenomenon.
在大鼠中研究了对未成熟动物全身给予海藻酸的短期和长期影响。对1至30日龄的大鼠全身给予海藻酸。对大鼠的行为和脑电图变化进行监测。为了研究海藻酸对癫痫易感性的影响，通过全身给予海藻酸在12日龄、18日龄和27日龄的大鼠中诱发癫痫持续状态。3天后使用点燃技术评估癫痫易感性。此外，另一组在全身给予海藻酸后发生癫痫持续状态的27日龄大鼠成年后进行点燃。幼鼠（1日龄）在给予海藻酸后出现行为性癫痫持续状态，6日龄开始出现发作期脑电图变化。给予海藻酸3天后点燃的15日龄和21日龄大鼠与对照组的点燃速度相同。然而，27日龄时接受海藻酸的30日龄大鼠比对照组更快地点燃至5期癫痫发作。27日龄时接受海藻酸并维持至成年的大鼠出现自发性反复癫痫发作，成年后比对照组更快点燃。这些结果表明，海藻酸对癫痫易感性的影响是一种年龄依赖性现象。
