Landmann R M, Müller F B, Perini C, Wesp M, Erne P, Bühler F R
Clin Exp Immunol. 1984 Oct;58(1):127-35.
Lymphocyte subpopulations were measured before and after physical and psychological stress in 15 healthy subjects and correlated with plasma catecholamine and cortisol levels. During psychological stress monocytes (P less than 0.05), NK (P less than 0.01), B cells (P less than 0.05) and heart rate (P less than 0.001) increased, while catecholamines remained unchanged. With physical stress granulocytes, monocytes and all lymphocyte subsets increased significantly, although B cells rose more than T cells and T (suppressor) cells more than T (helper) cells. Thus the ratio of T/B cells and of Th/Ts cells decreased (P less than 0.001 and P less than 0.01). Adrenaline and noradrenaline concentrations increased (P less than 0.001), while cortisol remained unchanged. There was a negative relationship between adrenaline and the Th/Ts cell ratio before and after stress (P less than 0.05). Lymphocyte subpopulations from a different group of 4 healthy subjects were analysed before and after isoproterenol infusion. There was a small increase in Ts and B cells only (P less than 0.1) and a decrease of the T/B cell ratio (P less than 0.05). The predominant enrichment of circulating B, Ts and NK cells during short lasting adrenergic activation, as well as the relationship of the T cell changes to plasma adrenaline, suggest an immunoregulatory effect of the sympathetic nervous system in stress.
对15名健康受试者在生理和心理应激前后的淋巴细胞亚群进行了检测，并将其与血浆儿茶酚胺和皮质醇水平进行关联分析。在心理应激期间，单核细胞（P<0.05）、自然杀伤细胞（NK，P<0.01）、B细胞（P<0.05）和心率（P<0.001）升高，而儿茶酚胺水平保持不变。在生理应激时，粒细胞、单核细胞和所有淋巴细胞亚群均显著增加，尽管B细胞的升高幅度大于T细胞，T（抑制）细胞的升高幅度大于T（辅助）细胞。因此，T/B细胞比值以及Th/Ts细胞比值下降（P<0.001和P<0.01）。肾上腺素和去甲肾上腺素浓度升高（P<0.001），而皮质醇水平保持不变。应激前后肾上腺素与Th/Ts细胞比值之间存在负相关关系（P<0.05）。对另一组4名健康受试者在输注异丙肾上腺素前后的淋巴细胞亚群进行了分析。仅Ts细胞和B细胞略有增加（P<0.1），T/B细胞比值下降（P<0.05）。在短暂的肾上腺素能激活过程中循环B细胞、Ts细胞和NK细胞的显著富集，以及T细胞变化与血浆肾上腺素之间的关系，提示交感神经系统在应激过程中具有免疫调节作用。
