兔体内C反应蛋白和脂蛋白的周转研究。
In vivo turnover studies of C-reactive protein and lipoproteins in the rabbit.
作者信息
Rowe I F, Baltz M L, Soutar A K, Pepys M B
出版信息
Clin Exp Immunol. 1984 Oct;58(1):245-52.
Abstract
Clearance from the plasma of 125I-labelled rabbit C-reactive protein (CRP) was significantly slower in animals undergoing an acute phase response (T1/2, mean +/- s.d., 6.48 +/- 1.4 h, n = 4) than in normal rabbits (3.17 +/- 0.4 h, n = 4), P less than 0.01. In contrast there was no difference between the rates of clearance of CRP in rabbits on a normal diet and hypercholesterolaemic rabbits, the plasma of which contained high levels of beta-VLDL with which CRP is known to form circulating complexes. Furthermore the apparent rates of clearance of 125I-labelled beta-VLDL, VLDL and LDL did not differ between normal rabbits and rabbits undergoing an acute phase response. The significance of these findings is discussed.
摘要
在经历急性期反应的动物中，125I标记的兔C反应蛋白（CRP）从血浆中的清除明显慢于正常兔（T1/2，平均值±标准差，6.48±1.4小时，n = 4）（正常兔为3.17±0.4小时，n = 4），P<0.01。相比之下，正常饮食的兔与高胆固醇血症兔的CRP清除率没有差异，高胆固醇血症兔的血浆中含有高水平的β-VLDL，已知CRP可与β-VLDL形成循环复合物。此外，正常兔与经历急性期反应的兔之间，125I标记的β-VLDL、VLDL和LDL的表观清除率没有差异。讨论了这些发现的意义。
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本文引用的文献
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Studies of acute phase protein. I. An immunohistochemical method for the localization of Cx-reactive protein in rabbits. Association with necrosis in local inflammatory lesions.急性期蛋白的研究。I. 兔体内C反应蛋白定位的免疫组织化学方法。与局部炎症病变中坏死的关联。
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