Baltz M L, Rowe I F, Pepys M B
Clin Exp Immunol. 1985 Jan;59(1):243-50.
The in vivo plasma clearance rate of the acute phase reactant C-reactive protein (CRP) was studied in mice and rats. The clearance rate of 125I-human CRP in mice and 125I-rat CRP in rats showed a T1/2 of approximately 4 h. The T1/2 was independent of circulating levels of CRP and was not affected by the presence of C-polysaccharide (CPS), a ligand to which CRP binds. However, in mice receiving sufficient CPS, more radioactivity localized to the spleen compared to mice receiving 125I-CRP only. 125I-CPS was rapidly cleared at the same rate by normal mice and by mice undergoing an acute phase response while rats cleared 125I-CPS more slowly despite having high circulating CRP concentrations. These findings suggest that CRP does not provide a mechanism for extremely rapid clearance of its ligands from the circulation, although the handling and subsequent fate of these ligands may be affected.
在小鼠和大鼠体内研究了急性期反应物C反应蛋白（CRP）的血浆清除率。小鼠体内125I-人CRP和大鼠体内125I-大鼠CRP的清除率显示半衰期约为4小时。半衰期与CRP的循环水平无关，且不受CRP结合配体C-多糖（CPS）存在的影响。然而，与仅接受125I-CRP的小鼠相比，接受足够CPS的小鼠脾脏中放射性更多。正常小鼠和处于急性期反应的小鼠以相同速率快速清除125I-CPS，而大鼠尽管循环CRP浓度很高，但清除125I-CPS的速度较慢。这些发现表明，CRP虽然可能影响这些配体的处理及其后续命运，但并未提供一种从循环中极其快速清除其配体的机制。
