Humphrey J H, Grennan D, Sundaram V
Eur J Immunol. 1984 Sep;14(9):859-64. doi: 10.1002/eji.1830140916.
F1----parental bone marrow chimeras between CBA and B10 mice were used to show that even after 1 year follicular dendritic cells (FDC), also termed dendritic reticular cells, are not derived from bone marrow stem cells. However clusters of cells wrapped in the dendritic processes of FDC, isolated by enzyme digestion of the spleen contain B cells originating from donor marrow. This implies that evidence for the presence of antigens such as Ia-like detected by others (Gerdes, J. and Stein, H., Clin. Exp. Immunol. 1982. 48: 348) by immunohistology in or on FDC clusters should be interpreted with caution. Deposition of immune complexes on mouse spleen FDC depends upon the presence of a radio- and cyclophosphamide-sensitive population of cells, although FDC themselves are resistant to such treatments. After whole body irradiation the capacity to localize fluorescein isothiocyanate-labeled aggregated human gamma globulin can be restored by normal or T-deprived spleen cells, but restoration requires an interval of more than 1 though less than 5 days. These findings are compatible with the evidence of Gray et al., Eur. J. Immunol. 1984. 14: 47, that in the rat immune complexes are transported to FDC by a sessile population of marginal zone lymphocytes, as first suggested by Brown et al., Immunology 1973. 24: 955.
F1代——CBA和B10小鼠之间的亲代骨髓嵌合体被用于证明，即使在1年后，滤泡树突状细胞（FDC），也称为树突状网状细胞，并非源自骨髓干细胞。然而，通过脾脏酶消化分离出的、包裹在FDC树突状突起中的细胞簇含有源自供体骨髓的B细胞。这意味着，其他人（格德斯、J.和施泰因、H.，《临床与实验免疫学》，1982年。48: 348）通过免疫组织化学在FDC簇内或其上检测到的诸如Ia样等抗原存在的证据应谨慎解读。免疫复合物在小鼠脾脏FDC上的沉积取决于一群对放射和环磷酰胺敏感的细胞的存在，尽管FDC本身对这些处理具有抗性。全身照射后，正常或T细胞缺失的脾细胞可恢复定位异硫氰酸荧光素标记的聚合人γ球蛋白的能力，但恢复需要超过1天但少于5天的间隔时间。这些发现与格雷等人（《欧洲免疫学杂志》，1984年。14: 47）的证据一致，即在大鼠中，免疫复合物由边缘区淋巴细胞的固定群体转运至FDC，这一观点最早由布朗等人（《免疫学》，1973年。24: 955）提出。
