Triolo G, Giardina E, Zarcone M R, Giordano C, Rinaldi A, Bompiani G D
Diabetologia. 1984 Jul;27 Suppl:157-9. doi: 10.1007/BF00275677.
The relative contribution of secretory IgA, monomeric and polymeric IgA and IgA/secretory component-containing immune complexes was investigated in sera of diabetic patients. Secretory IgA and immune complexes containing IgA and secretory component seem to participate in the hyper-IgA of patients with Type 2 (non-insulin-dependent) diabetes only, suggesting an altered hepatic clearance via secretory component receptors on hepatocytes. In Type 1 (insulin-dependent) diabetes, the high serum IgA levels might be explained by an increase in IgA production in response to antigenic stimuli. Evidence is also accumulated that immune complexes containing IgA of mucosal origin may be involved in microangiopathy production in Type 2 diabetes.
研究了分泌型IgA、单体和多聚IgA以及含IgA/分泌成分的免疫复合物在糖尿病患者血清中的相对贡献。分泌型IgA以及含IgA和分泌成分的免疫复合物似乎仅参与2型（非胰岛素依赖型）糖尿病患者的高IgA血症，提示通过肝细胞上的分泌成分受体导致肝脏清除功能改变。在1型（胰岛素依赖型）糖尿病中，高血清IgA水平可能是由于对抗抗原刺激时IgA产生增加所致。也有越来越多的证据表明，源自黏膜的含IgA免疫复合物可能参与2型糖尿病微血管病变的发生。
