Triolo G, Giardina E, Rinaldi A, Bompiani G D
Clin Immunol Immunopathol. 1984 Feb;30(2):169-77. doi: 10.1016/0090-1229(84)90051-5.
Sera of patients with type 1 and type 2 diabetes were examined for IgA- and insulin-containing immune complexes (IgA-ICs, ICs-insulin) using a solid-phase anti-C3 enzyme immunoassay. IgM-ICs and IgG-ICs were also investigated. IgA-ICs were detected in 6 of 26 type 1 diabetics, in 9 of 25 insulin-treated type 2 diabetics, and in 8 of 34 type 2 diabetics on oral hypoglycemic agents, but only in 2 sex- and age-matched controls. ICs-insulin was detected in 9 of 25 type 1 diabetics and in 1 of 19 insulin-treated type 2 diabetics, irrespective of the time of insulin treatment. ICs-insulin did not appear to be related to the presence of microangiopathy. IgA-ICs were found to be associated with the presence of microangiopathy, suggesting that they may play a role in the pathogenesis of the late diabetic complications.
采用固相抗C3酶免疫分析法检测1型和2型糖尿病患者血清中的含IgA和胰岛素的免疫复合物（IgA免疫复合物、胰岛素免疫复合物）。同时也对IgM免疫复合物和IgG免疫复合物进行了研究。在26例1型糖尿病患者中有6例检测到IgA免疫复合物，25例接受胰岛素治疗的2型糖尿病患者中有9例检测到，34例接受口服降糖药治疗的2型糖尿病患者中有8例检测到，而在2例性别和年龄匹配的对照者中仅2例检测到。在25例1型糖尿病患者中有9例检测到胰岛素免疫复合物，19例接受胰岛素治疗的2型糖尿病患者中有1例检测到，与胰岛素治疗时间无关。胰岛素免疫复合物似乎与微血管病变的存在无关。发现IgA免疫复合物与微血管病变的存在有关，这表明它们可能在糖尿病晚期并发症的发病机制中起作用。
