人类胎儿器官碱性磷酸酶。

Human fetal organ alkaline phosphatases.

作者信息

Miki K, Oda T, Suzuki H, Niwa H, Endo Y, Iino S, Miyazaki J, Hirano K, Sugiura M

出版信息

Clin Chim Acta. 1978 Apr 17;85(2):115-24. doi: 10.1016/0009-8981(78)90230-9.

Abstract

The properties of human fetal alkaline phosphatase (ALP) have been compared with those of purified human adult hepatic and intestinal ALPs. The ALPs from different human fetal organs were divided into two groups. One terminated universal type was presented in fetal liver, spleen, adrenal, kidney, lung, heart, pancreas, thymus and bone, and was similar to adult hepatic-type ALP. The other terminated intestinal type was presented in fetal intestine and meconium and was similar to adult intestinal ALP. The activity of human fetal intestinal ALP increased markedly with the advance of intra-uterine life during fetal development, and that of human fetal thymus ALP increased slightly.

摘要

已将人胎儿碱性磷酸酶（ALP）的特性与纯化的成人肝和肠碱性磷酸酶的特性进行了比较。来自不同人胎儿器官的碱性磷酸酶被分为两组。一种终末通用型存在于胎儿的肝脏、脾脏、肾上腺、肾脏、肺、心脏、胰腺、胸腺和骨骼中，与成人肝型碱性磷酸酶相似。另一种终末肠型存在于胎儿肠道和胎粪中，与成人肠碱性磷酸酶相似。在胎儿发育过程中，人胎儿肠碱性磷酸酶的活性随着子宫内生命的进展而显著增加，而人胎儿胸腺碱性磷酸酶的活性略有增加。