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溶血红细胞因子和铁增强副溶血性弧菌的毒力

Enhancement of Vibrio parahaemolyticus virulence by lysed erythrocyte factor and iron.

作者信息

Karunasagar I, Joseph S W, Twedt R M, Hada H, Colwell R R

出版信息

Infect Immun. 1984 Oct;46(1):141-4. doi: 10.1128/iai.46.1.141-144.1984.

Abstract

The effect of lysed blood on the virulence of Vibrio parahaemolyticus for mice was investigated. A factor present in lysed erythrocytes was found to greatly reduce the 50% lethal dose of V. parahaemolyticus for mice. Similar effects were observed with ferric ammonium citrate and manganous sulfate. V. parahaemolyticus grown in brain heart infusion containing lysed erythrocyte factor appeared to produce a lethal toxin which was either inapparent or absent when the organism was grown in brain heart infusion alone.

摘要

研究了溶血对副溶血性弧菌对小鼠毒力的影响。发现溶血红细胞中存在的一种因子能大大降低副溶血性弧菌对小鼠的半数致死剂量。柠檬酸铁铵和硫酸锰也观察到类似效果。在含有溶血红细胞因子的脑心浸液中生长的副溶血性弧菌似乎产生了一种致命毒素,而当该菌仅在脑心浸液中生长时,这种毒素要么不明显,要么不存在。

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