使用乙酰次氟酸酯对18F标记的5-氟尿嘧啶进行简单合成。
A simple synthesis of 18F-labelled 5-fluorouracil using acetylhypofluorite.
作者信息
Diksic M, Farrokhzad S, Yamamoto Y L, Feindel W
出版信息
Int J Nucl Med Biol. 1984;11(2):141-2. doi: 10.1016/0047-0740(84)90049-4.
PMID:6480255
Abstract
18F-labelled 5-fluorouracil was synthesized by reacting labelled acetylhypofluorite in situ with uracil. Evaporation in the presence of triethylamine yielded 18F-5-fluorouracil in an overall radiochemical yield of about 20-30%. The solution was purified by passing it through a Sep-Pak column.
摘要
通过使标记的乙酰次氟酸与尿嘧啶原位反应合成了18F标记的5-氟尿嘧啶。在三乙胺存在下蒸发，得到18F-5-氟尿嘧啶，总放射化学产率约为20-30%。通过Sep-Pak柱对溶液进行纯化。
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