Adam M J, Ruth T J, Grierson J R, Abeysekera B, Pate B D
J Nucl Med. 1986 Sep;27(9):1462-6.
The synthesis of L-[18F]6-fluorodopa (2.4-10.6 mCi) was done by passing gaseous [18F]acetyl hypofluorite through a solution of L-methyl-N- acetyl-[beta-(3-methoxy-4-acetoxyphenyl)]alaninate in acetic acid at room temperature followed by the hydrolysis of the intermediate products with concentrated hydriodic acid. The desired fluorodopa isomer was isolated in 8% EOB radiochemical yield by high performance liquid chromatography in an overall synthesis time of 100 min.
L-[18F]6-氟多巴（2.4 - 10.6毫居里）的合成是通过在室温下将气态[18F]次氟酸乙酰酯通入L-甲基-N-乙酰基-[β-(3-甲氧基-4-乙酰氧基苯基)]丙氨酸甲酯的乙酸溶液中，随后用浓氢碘酸水解中间产物来完成的。通过高效液相色谱法，在100分钟的总合成时间内，以8%的放化产率分离得到所需的氟多巴异构体。
