Shani J, Scott J Z, Young D, Wolf W
Int J Nucl Med Biol. 1984;11(2):149-52. doi: 10.1016/0047-0740(84)90051-2.
The feasibility of using radioiodinated prolactin for early detection of solid mammary tumors was studied in the rat. Radioiodinated prolactin was first injected into tumored and control rats in order to define the localization of the labeled hormone in their target organs, then it was injected into extracorporeal blood-loop of tumored and healthy rats, in order to study its clearance in those animals. At 15 min post injection, 75-82% of the labeled hormone was recovered, of which 4-5% were counted in the tumor. Deiodination was apparent only 30 min after injection. As much as high deposition of the labeled hormone was not achieved in the hormone-dependent tumor lines investigated, some of the pitfalls that may be encountered are documented. The clearance of the labeled prolactin as determined by the blood-loop technique is 3.3 min in the R3230 tumor, and 6.4 min in the 13762 mammary tumor. The healthy rats had a blood clearance of 4.6 min.
在大鼠中研究了使用放射性碘化催乳素早期检测实体乳腺肿瘤的可行性。首先将放射性碘化催乳素注射到患肿瘤的大鼠和对照大鼠体内，以确定标记激素在其靶器官中的定位，然后将其注射到患肿瘤的大鼠和健康大鼠的体外血液循环中，以研究其在这些动物体内的清除情况。注射后15分钟，回收了75 - 82%的标记激素，其中4 - 5%在肿瘤中被计数。脱碘仅在注射后30分钟才明显。在所研究的激素依赖性肿瘤系中，虽然未实现标记激素的高沉积，但记录了一些可能遇到的陷阱。通过血液循环技术测定，标记催乳素在R3230肿瘤中的清除时间为3.3分钟，在13762乳腺肿瘤中的清除时间为6.4分钟。健康大鼠的血液清除时间为4.6分钟。
