白细胞迁移试验中刺激作为细胞超敏反应指标的意义——以Tamm-Horsfall糖蛋白为抗原的研究
The significance of stimulation in the leucocyte migration test as an indicator of cellular hypersensitivity--studies using Tamm-Horsfall glycoprotein as antigen.
作者信息
Cochrane A M, Tsantoulas D C, McFarlane I G, Eddleston A L, Williams R
出版信息
Clin Exp Immunol. 1978 Feb;31(2):174-7.
To determine whether stimulation of leucocyte migration in the presence of an antigen is a reliable indicator of sensitization, the results of leucocyte migration using a kidney antigen (Tamm-Horsfall glycoprotein) were compared with those of lymphocyte transformation using the same antigen and with the lymphocyte cytotoxicity for cells known to synthesize this antigen. There was a close correlation between the results of all three tests and these findings strongly suggest that the stimulation of leucocyte migration as an immunological phenomenon was as valid as inhibition in demonstrating sensitization.
为了确定在存在抗原的情况下白细胞迁移的刺激是否是致敏的可靠指标，将使用肾脏抗原（Tamm-Horsfall糖蛋白）进行白细胞迁移的结果与使用相同抗原进行淋巴细胞转化的结果以及对已知合成该抗原的细胞的淋巴细胞细胞毒性结果进行了比较。所有三项测试的结果之间存在密切相关性，这些发现强烈表明，作为一种免疫现象，白细胞迁移的刺激在证明致敏方面与抑制作用同样有效。
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