Müller-Vahl H, Pabst R
Int J Tissue React. 1984;6(3):251-4.
Ten drugs or vaccines commonly given to patients by intramuscular injection were injected into the femoral artery of normal young anaesthetized pigs, in order to establish an animal model for macroscopically identifiable aseptic tissue necrosis (Nicolau syndrome). Despite the wide range of constituents and chemical groupings in the drugs which had caused Nicolau syndrome in patients, when injected into the pigs a typical pattern of reactions could be observed for many of them, as follows: the leg contracted rapidly, the skin area supplied by this artery initially became pale and then bluish-red with an irregular reticular appearance before finally tissue necrosis developed. These reactions are comparable to the symptoms of Nicolau syndrome in man. However, no reactions were seen when drugs or vaccines which have not been known to cause aseptic necrosis in man, e.g. tetanus toxoid, influenza vaccine or triamcinolon, were injected i.a.
将常用于给患者进行肌肉注射的10种药物或疫苗注入正常的年轻麻醉猪的股动脉，以建立一种可通过肉眼识别无菌性组织坏死（尼科劳综合征）的动物模型。尽管导致患者出现尼科劳综合征的药物成分和化学类别范围广泛，但当将它们注入猪体内时，其中许多药物都能观察到典型的反应模式，如下：腿部迅速收缩，该动脉供血区域的皮肤最初变白，然后变为蓝红色，呈现不规则网状外观，最终发展为组织坏死。这些反应与人的尼科劳综合征症状相似。然而，当注入已知不会在人类中引起无菌性坏死的药物或疫苗（例如破伤风类毒素、流感疫苗或曲安奈德）时，未观察到任何反应。
