Alho H, Partanen M, Koistinaho J, Vaalasti A, Hervonen A
Histochemistry. 1984;80(5):457-62. doi: 10.1007/BF00495434.
The catecholamine content and morphology of the superior cervical and the hypogastric ganglion and the carotid body were studied in Spontaneously Hypertensive Rats (SHR) before (at the age of 6 weeks) and after (at the age of 20 weeks) becoming hypertensive, with Wistar Kyoto (WKY) rats as controls. The study was performed by formaldehyde-induced fluorescence method combined with quantitative microfluorimetry of catecholamines. At the age of 6 weeks the only significant difference observed between the rat strains was a greater number of small intensely fluorescent (SIF) cells in the superior cervical ganglion of SHR. At the age of 20 weeks the fluorescence intensity was higher in the principal neurons of the superior cervical ganglion and in glomus cells of the carotid body of SHR compared to WKY. The volumes of superior cervical ganglion and carotid body were larger in 20-week-old SHR compared to WKY. In the hypogastric ganglion differences were not found between SHR and WKY rats. The present results show differences in the superior cervical ganglion and in the carotid body of adult SHR compared to controls. These differences develop during the time period when the SHR become hypertensive, and might be functionally significant in the regulation or maintenance of the increased blood pressure in SHR rats.
采用甲醛诱导荧光法结合儿茶酚胺定量显微荧光测定法，以Wistar Kyoto（WKY）大鼠作为对照，研究了自发性高血压大鼠（SHR）在出现高血压之前（6周龄）和之后（20周龄）颈上神经节、腹下神经节以及颈动脉体的儿茶酚胺含量和形态。在6周龄时，观察到大鼠品系间唯一显著的差异是SHR颈上神经节中小而强荧光（SIF）细胞数量更多。在20周龄时，与WKY相比，SHR颈上神经节的主神经元以及颈动脉体的球细胞中的荧光强度更高。与WKY相比，20周龄SHR的颈上神经节和颈动脉体体积更大。在腹下神经节中，未发现SHR和WKY大鼠之间存在差异。目前的结果表明，与对照组相比，成年SHR的颈上神经节和颈动脉体存在差异。这些差异在SHR出现高血压的时间段内形成，可能在SHR大鼠血压升高的调节或维持中具有功能意义。
