Ariano M A, Kenny S L
Brain Res. 1987 Jul 7;415(1):115-21. doi: 10.1016/0006-8993(87)90274-5.
The localization and distribution of catecholamines, selected neuropeptides, and the cyclic nucleotide second messengers has been determined in the superior cervical ganglion of the stroke-prone variant of the spontaneously hypertensive rat (SHR) and its normotensive Wistar-kyoto (WKY) control. Significant alteration in the frequency of occurrence of dopaminergic small intensely fluorescent cell clusters was seen in the stroke-prone variant of the SHR. The immunofluorescent localization of cyclic AMP (cAMP) and cyclic GMP (cGMP) were also changed in the stroke-prone variant, as was the immunofluorescent staining quantity of the neuropeptides somatostatin and substance P. The morphological pattern of staining for the various compounds in the normotensive control (WKY) was equivalent to the Sprague-Dawley rat strain. The implications of the altered neurochemistry in the superior cervical ganglion on the high blood pressure, and the predisposition for stroke in this strain are discussed.
已确定了儿茶酚胺、选定的神经肽以及环核苷酸第二信使在自发性高血压大鼠（SHR）易中风变种的颈上神经节及其正常血压的Wistar-kyoto（WKY）对照中的定位和分布。在SHR易中风变种中，观察到多巴胺能小而强荧光细胞簇的出现频率有显著改变。环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）的免疫荧光定位在易中风变种中也发生了变化，神经肽生长抑素和P物质的免疫荧光染色量同样如此。正常血压对照（WKY）中各种化合物的染色形态模式与Sprague-Dawley大鼠品系相同。讨论了颈上神经节中神经化学变化对该品系高血压及中风易感性的影响。
