Dahl M V, Roering M J
J Am Acad Dermatol. 1984 Sep;11(3):477-9. doi: 10.1016/s0190-9622(84)70194-0.
Patch tests with aqueous solutions of the irritating detergent sodium lauryl sulfate (SLS) elicit varying degrees of inflammation from subject to subject and from site to site. For an investigation of the causes of this variability, two patch tests with 10% aqueous solutions of SLS were applied to adjacent areas of ventral forearm skin of eighteen volunteers. In one test the water vehicle was allowed to evaporate from the patch test unit before the patches were applied. After 22 hours the patch tests were removed, and 2 hours later the degree of inflammation was graded. Less inflammation was present at the site of the dry patch test in fifteen of eighteen subjects, and the score of inflammation between each pair was significantly less at the dry patch test site (p less than 0.001). These studies show that evaporation of water from aqueous solutions can influence the irritating potential of SLS on human skin.
用刺激性去污剂月桂醇硫酸酯钠（SLS）的水溶液进行斑贴试验，不同个体之间以及不同部位之间会引发不同程度的炎症。为了研究这种变异性的原因，对18名志愿者的前臂内侧皮肤相邻区域进行了两次10% SLS水溶液的斑贴试验。在一次试验中，在贴敷斑贴试验装置之前，让水载体从该装置中蒸发。22小时后取下斑贴试验，2小时后对炎症程度进行分级。18名受试者中有15名在干斑贴试验部位的炎症较轻，并且在干斑贴试验部位，每对之间的炎症评分显著更低（p小于0.001）。这些研究表明，水溶液中的水分蒸发会影响SLS对人体皮肤的刺激潜能。
