Dahl M V, Trancik R J
Contact Dermatitis. 1977 Oct;3(5):263-6. doi: 10.1111/j.1600-0536.1977.tb03672.x.
Irritant reactions were induced on the forearms of 10 normal subjects with 10% aqueous sodium lauryl sulfate under patch test occlusion for 24 h. Test sites were observed at 24, 26, 28, 30, 48, 72 and 96 h and the degree of inflammation recorded. Inflammation was most prominent at 28 h and decreased in intensity over the time course of the study. Inflammation at 48 and 72 h was similar to when patches were removed. This suggests that inflammatory responses in skin for at least certain irritants like sodium lauryl sulfate do slowly decrease in intensity after 48 h. However, the inflammatory response may initially accelerate after patch test removal and remain intense for at least 48 h. Fading of irritant reactions by 48 or 72 h may not reliably distinguish irritant from allergic patch test reactions. This does not refute the usefulness of a delayed (96 h) reading since inflammation from sodium lauryl sulfate had decreased significantly by this time.
在10名正常受试者的前臂上进行斑贴试验，用10%的月桂醇硫酸盐水溶液封闭敷贴24小时，以诱导刺激性反应。在24、26、28、30、48、72和96小时观察试验部位，并记录炎症程度。炎症在28小时时最为明显，且在研究过程中强度逐渐降低。48小时和72小时时的炎症情况与去除贴片时相似。这表明，对于至少某些刺激性物质如十二烷基硫酸钠，皮肤中的炎症反应在48小时后强度确实会缓慢降低。然而，炎症反应在去除斑贴试验后可能最初会加速，并至少持续48小时保持强烈。在48或72小时时刺激性反应的消退可能无法可靠地区分刺激性斑贴试验反应和过敏性斑贴试验反应。这并不否定延迟（96小时）读数的有用性，因为此时十二烷基硫酸钠引起的炎症已显著减轻。
