Traber D L, Adams T, Henriksen N, Traber L D
J Trauma. 1984 Sep;24(9):835-40. doi: 10.1097/00005373-198409000-00010.
Endotoxin (0.75 micrograms/kg) was administered to unanesthetized sheep with and without premedication with ibuprofen, a cyclooxygenase inhibitor, and diphenhydramine, an antihistamine. The effect of the endotoxin on cardiopulmonary and lung lymph data and their alteration by the drug regimen was assessed. The cardiopulmonary responses to endotoxin can be defined into two phases. In phase I there is an elevation in protein-poor lung lymph flow, in pulmonary artery pressure (PA), and in hematocrit, and a reduction in cardiac index and leukocyte count. Phase II occurs late and shows much the same changes as phase I except that the PA is not as high and the lymph protein is increased. The drug combination (ibuprofen and diphenhydramine) virtually eliminates the phase I response. The phase II changes in lymph flow and protein content are affected by diphenhydramine but not ibuprofen. The cardiovascular changes which occur during this period are not affected by either agent.
给未麻醉的绵羊注射内毒素（0.75微克/千克），部分绵羊预先使用了环氧化酶抑制剂布洛芬和抗组胺药苯海拉明，部分未使用。评估了内毒素对心肺和肺淋巴数据的影响以及药物方案对其的改变。内毒素引起的心肺反应可分为两个阶段。在第一阶段，蛋白质含量低的肺淋巴流量、肺动脉压（PA）和血细胞比容升高，心脏指数和白细胞计数降低。第二阶段出现较晚，除了肺动脉压没有那么高且淋巴蛋白增加外，显示出与第一阶段大致相同的变化。药物组合（布洛芬和苯海拉明）几乎消除了第一阶段的反应。淋巴流量和蛋白质含量的第二阶段变化受苯海拉明影响，但不受布洛芬影响。在此期间发生的心血管变化不受任何一种药物的影响。
