Ghosh S, Paweletz N, Ghosh I
Chromosoma. 1978 Feb 24;65(4):293-300. doi: 10.1007/BF00286409.
A high degree of mitotic asynchrony is reported for spontaneously arising multinucleate cells of HeLa and Pt-K1, tissue culture cell lines. Neither nuclear number, nor nuclear size nor the presence or absence of nucleoli, could be directly related to the asynchronous behaviour of the cells. Suboptimal levels of nutrients led to a higher frequency of asynchrony. A partial compartmentation of the cytoplasm could be detected in some of the multinucleate cells. The compartmentation of the cytoplasm may lead to an uneven distribution of inducer and non-inducer metabolites. All these factors together may be responsible for the high degree of mitotic asynchrony.
据报道，在组织培养细胞系HeLa和Pt-K1自发形成的多核细胞中，有高度的有丝分裂不同步现象。细胞核数量、细胞核大小以及核仁的有无，均与细胞的不同步行为无直接关联。营养物质水平欠佳会导致更高频率的不同步。在一些多核细胞中可检测到细胞质的部分分隔现象。细胞质的分隔可能导致诱导剂和非诱导剂代谢产物分布不均。所有这些因素共同作用，可能是有丝分裂高度不同步的原因。
