Slotnick B M, Schoonover F W
Department of Psychology, American University, Washington, DC 20016.
Neurosci Biobehav Rev. 1992 Winter;16(4):453-72. doi: 10.1016/s0149-7634(05)80187-3.
Rats were trained using operant conditioning to detect isoamyl acetate vapor generated by an olfactometer. They received lesions of olfactory pathways and were tested for retention of the odor detection task and trained on two-odor tasks. Deficits in odor detection and two-odor discrimination were related to the extent to which lesions disconnected the olfactory bulb from the forebrain. Transection of only the lateral olfactory tract, only the anterior limb of the anterior commissure, or lesions of the olfactory tubercle had little effect but combined lesions of these structures produced severe deficits in both odor detection and discrimination. Only rats with almost complete transection of the olfactory peduncle or cortex were anosmic; those with transections that spared a small segment of tissue between the olfactory bulb and olfactory cortex had detectable olfactory function. The results are discussed with regard to efferent connections of the olfactory bulb.
使用操作性条件反射训练大鼠来检测嗅觉计产生的乙酸异戊酯蒸气。它们接受嗅觉通路损伤，并接受气味检测任务的记忆测试，并进行双气味任务训练。气味检测和双气味辨别缺陷与损伤使嗅球与前脑断开连接的程度有关。仅横断外侧嗅束、仅前连合前肢或嗅结节损伤影响很小，但这些结构的联合损伤会导致气味检测和辨别出现严重缺陷。只有嗅柄或皮质几乎完全横断的大鼠才会嗅觉缺失；那些在嗅球和嗅觉皮质之间保留一小段组织的横断大鼠仍具有可检测的嗅觉功能。结合嗅球的传出连接对结果进行了讨论。
