Sonnenfeld G
Oncology. 1983;40(1):52-6. doi: 10.1159/000225691.
Mouse embryo fibroblast cell cultures were treated with chemicals that are major components of sidestream (passive) cigarette smoke. These components were 4-aminobiphenyl and aniline-HCl. The cultures produced severely reduced levels of alpha/beta interferon after challenge with polyriboinosinic-polyribocytidylic acid when compared to control cultures. Treatment of additional cell cultures with 2-methylquinoline, and intermediate-level component of sidestream tobacco smoke, or hydrazine-sulfate, a minor component of sidestream tobacco smoke but a major component of mainstream (active) tobacco smoke, also resulted in inhibition of interferon induction with polyriboinosinic acid-polyribocytidylic acid. Therefore, treatment of the cell cultures with chemicals that are carcinogenic was equally effective in inhibiting alpha/beta interferon induction without regard to the sidestream or mainstream smoke origin of the chemical.
小鼠胚胎成纤维细胞培养物用侧流（被动）香烟烟雾的主要成分化学物质进行处理。这些成分是4-氨基联苯和盐酸苯胺。与对照培养物相比，在用聚肌苷酸-聚胞苷酸攻击后，培养物产生的α/β干扰素水平严重降低。用2-甲基喹啉（侧流烟草烟雾的一种中级成分）或硫酸肼（侧流烟草烟雾的一种次要成分但主流（主动）烟草烟雾的主要成分）处理其他细胞培养物，也导致聚肌苷酸-聚胞苷酸诱导干扰素受到抑制。因此，用致癌化学物质处理细胞培养物在抑制α/β干扰素诱导方面同样有效，而不考虑该化学物质来自侧流还是主流烟雾。
