[蒽环类抗生素5-亚氨基柔红霉素的电化学还原。还原产物的分离与结构解析]
[Electrochemical reduction of the anthracycline antibiotic 5-iminodaunorubicin. Isolation and structural clarification of the reduction products].
作者信息
Tresselt D, Ihn W, Horn G, Berg H
出版信息
Pharmazie. 1984 Jun;39(6):417-9.
PMID:6483947
Abstract
After electrochemical reduction of the potential cancer chemotherapeutic 5-iminodaunorubicine two new compounds, were isolated purely by chromatographic separation. Based on 1H-NMR, IR-, UV/VIS- and MS-investigations the one reaction product was identified as 7-desoxy-5-iminodaunorubicinone as expected, while the other was proofed as 9-acetyl-9,12-dihydroxy-4-methoxy-7,8,9,10-tetrahydroxy-6,11-naphthac enchinone.
摘要
在对潜在的癌症化疗药物5-亚氨基柔红霉素进行电化学还原后，通过色谱分离法纯分离出两种新化合物。基于1H-NMR、IR、UV/VIS和MS研究，一种反应产物正如预期被鉴定为7-脱氧-5-亚氨基柔红霉素酮，而另一种被证明是9-乙酰基-9,12-二羟基-4-甲氧基-7,8,9,10-四羟基-6,11-萘并蒽醌。
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