Carnow B W
Environ Health Perspect. 1978 Feb;22:17-21. doi: 10.1289/ehp.782217.
Data are presented which suggest that cigarette smoking, and to a lesser degree, urban pollution as indexed by benzo[a]pyrene are etiologic factors in the causation of lung cancer. The dose--response relationship to benzo[a]pyrene to lung cancer death rate in the urban community was estimated by using data on lung cancer deaths among coke oven workers. It appears to be an excess of 2--5 mumg/m3 of benzo[a]pyrene per 100,000 population, suggesting that a lifetime community exposure to benzo[a]pyrene on a continuing basis may have a greater impact on lung deaths in the community than that considered by the Royal College of Physicians.
所呈现的数据表明,吸烟以及程度稍轻的以苯并[a]芘为指标的城市污染是肺癌病因中的致病因素。通过使用炼焦炉工人肺癌死亡数据,估算了城市社区中苯并[a]芘与肺癌死亡率的剂量反应关系。每10万人口中似乎存在超过2至5微克/立方米的苯并[a]芘,这表明社区居民持续终生接触苯并[a]芘对社区肺癌死亡的影响可能比皇家内科医师学院所考虑的更大。