Pacsa A S
Lancet. 1977 Feb 12;1(8007):330-1. doi: 10.1016/s0140-6736(77)91134-5.
In 297 pregnant women serum-levels of antibody to rubella virus were determined by haemagglutination inhibition, and serum-levels of antibodies to herpes-simplex virus and Toxoplasma gondii were measured by indirect immunofluorescence tests. Sera of age-matched non-pregnant women with intrauterine devices were also tested for the antibodies. A lower level of humoral immunity was found in the pregnant women than in the controls, and this fell further as pregnancy progressed. Investigation of serum-samples taken at 14 weeks' gestation, at delivery, and 30-45 days post-partum revealed that after delivery humoral immunity to rubella virus returned to the levels of early gestation. Of 44 amniotic-fluid samples collected from pregnancies terminated at 11-14 wk and examined for antiviral activity to herpes-simplex virus and polio-virus, 7 exerted an antiviral effect which could be linked with the protein (other than alpha1-fetoprotein) fraction of the amniotic fluid.
对297名孕妇采用血凝抑制法测定风疹病毒抗体血清水平，采用间接免疫荧光试验检测单纯疱疹病毒和弓形虫抗体血清水平。对年龄匹配的带宫内节育器的非孕妇血清也进行了抗体检测。发现孕妇的体液免疫水平低于对照组，且随着妊娠进展进一步下降。对妊娠14周、分娩时及产后30 - 45天采集的血清样本进行调查发现，分娩后对风疹病毒的体液免疫恢复到妊娠早期水平。从妊娠11 - 14周终止妊娠的孕妇中收集了44份羊水样本，检测其对单纯疱疹病毒和脊髓灰质炎病毒的抗病毒活性，其中7份具有抗病毒作用，这可能与羊水中的蛋白质（α1-甲胎蛋白除外）部分有关。
