Murrah V A, Batsakis J G
Department of Pathology, University of Texas Health Science Center, San Antonio.
Ann Otol Rhinol Laryngol. 1994 Aug;103(8 Pt 1):660-3. doi: 10.1177/000348949410300816.
Proliferative verrucous leukoplakia and hyperplasia are irreversible clinicopathologic lesions of the oral cavity and upper respiratory tract with considerable potential for evolving into verrucous or other forms of squamous cell carcinoma. Proliferative verrucous leukoplakia is a disease of the oral cavity in which verrucous hyperplasia is a part of its developmental spectrum. Verrucous hyperplasia, at other head and neck mucosal sites, may be associated with papillomas or be a de novo lesion. Human papillomavirus, as a cofactor, plays a role in some of the lesions. In the instance of verrucous hyperplasia, the authors consider it an early form of verrucous carcinoma and recommend it be treated accordingly.
增殖性疣状白斑和增生是口腔和上呼吸道的不可逆临床病理病变，具有发展为疣状或其他形式鳞状细胞癌的相当大潜力。增殖性疣状白斑是一种口腔疾病，其中疣状增生是其发展谱系的一部分。在其他头颈部黏膜部位，疣状增生可能与乳头状瘤相关或为新发病变。人乳头瘤病毒作为一种辅助因素，在某些病变中起作用。对于疣状增生，作者认为它是疣状癌的早期形式，并建议相应地进行治疗。
