Douglas N J, White D P, Weil J V, Pickett C K, Martin R J, Hudgel D W, Zwillich C W
Am Rev Respir Dis. 1982 Mar;125(3):286-9. doi: 10.1164/arrd.1982.125.3.286.
Ventilatory drives are presumed to be important in the maintenance of ventilation during sleep. Although the hypercapnic ventilatory response has been shown to decrease during sleep, the hypoxic ventilatory response (HVR) has not been well studied in humans. We therefore measured the ventilatory response to isocapnic hypoxia in 6 sleeping men. The HVR, measured as the slope of the relation between ventilation and decreasing hemoglobin saturation, was significantly lower in all sleep stages than in wakefulness (1.07 +/- 0.19 SEM L/min/%saturation). The HVR decreased to two thirds of this waking value in non-REM sleep (0.63 +/- 0.09 L/min/%saturation) with a further significant decrease in REM sleep when HVR was less than one third of the waking value (0.33 +/- 0.04 L/min/%saturation). The decreased HVR may help to explain the REM-sleep-related hypoxemia found in normal persons and patients with various cardiovascular diseases.
通气驱动被认为在睡眠期间维持通气方面很重要。尽管高碳酸血症通气反应在睡眠期间已被证明会降低，但低氧通气反应（HVR）在人类中尚未得到充分研究。因此，我们测量了6名睡眠男性对等碳酸血症性低氧的通气反应。以通气与血红蛋白饱和度降低之间关系的斜率来衡量的HVR，在所有睡眠阶段均显著低于清醒时（1.07±0.19 SEM升/分钟/饱和度百分比）。在非快速眼动睡眠中，HVR降至清醒值的三分之二（0.63±0.09升/分钟/饱和度百分比），在快速眼动睡眠中进一步显著降低，此时HVR小于清醒值的三分之一（0.33±0.04升/分钟/饱和度百分比）。HVR降低可能有助于解释在正常人和各种心血管疾病患者中发现的与快速眼动睡眠相关的低氧血症。
