肠道微生物群在人体内醋硝香豆素还原代谢中的作用。
The role of the intestinal microflora in the reductive metabolism of acenocoumarol in man.
作者信息
Thijssen H H, Baars L G, Hazen M J, Van den Bogaard A E
出版信息
Br J Clin Pharmacol. 1984 Aug;18(2):247-9. doi: 10.1111/j.1365-2125.1984.tb02463.x.
Abstract
Although the oral anticoagulant acenocoumarol (AC) is very effectively metabolized by the intestinal microflora to its amino metabolite, under clinical conditions this route of AC-disposition is of no importance because the compound is rapidly absorbed from its pharmaceutical application form. Only when the gastro-intestinal absorption is retarded, for instance by using a capsule as vehiculum, are appreciable amounts of reduced metabolites recovered in urine.
摘要
尽管口服抗凝剂醋硝香豆素（AC）可被肠道微生物群非常有效地代谢为其氨基代谢物，但在临床情况下，AC的这种处置途径并不重要，因为该化合物从其药物剂型中迅速吸收。只有当胃肠道吸收受阻时，例如使用胶囊作为载体，才会在尿液中回收相当数量的还原代谢物。
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