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本文引用的文献

1
The pharmacokinetics of intravenous tinidazole in man.静脉注射替硝唑在人体中的药代动力学。
J Antimicrob Chemother. 1981 Oct;8(4):343-4. doi: 10.1093/jac/8.4.343.
2
Infection with non-sporing anaerobes in obstetrics and gynaecology. A review.妇产科非芽孢厌氧菌感染。综述。
Br J Obstet Gynaecol. 1980 Oct;87(10):846-55. doi: 10.1111/j.1471-0528.1980.tb04435.x.
3
Penetration of metronidazole and tinidazole into the aqueous humor in man.甲硝唑和替硝唑在人体房水中的渗透情况。
Chemotherapy. 1983;29(3):188-91. doi: 10.1159/000238196.
4
Comparative pharmacokinetics of metronidazole and tinidazole as influenced by administration route.甲硝唑和替硝唑给药途径对其比较药代动力学的影响
Antimicrob Agents Chemother. 1983 May;23(5):721-5. doi: 10.1128/AAC.23.5.721.
5
Tinidazole in anaerobic infections: a review of its antibacterial activity, pharmacological properties and therapeutic efficacy.替硝唑在厌氧菌感染中的应用：抗菌活性、药理特性及治疗效果综述
Drugs. 1982 Aug;24(2):85-117. doi: 10.2165/00003495-198224020-00001.
6
Penetration of the blood brain barrier by metronidazole and tinidazole.甲硝唑和替硝唑对血脑屏障的穿透作用。
J Antimicrob Chemother. 1977 May;3(3):239-45. doi: 10.1093/jac/3.3.239.
7
Determination of metronidazole and misonidazole and their metabolites in plasma and urine by high-performance liquid chromatography.高效液相色谱法测定血浆和尿液中的甲硝唑、米索硝唑及其代谢产物
J Chromatogr. 1978 Jul 1;146(1):163-6. doi: 10.1016/s0378-4347(00)81303-1.
8
Incidence of aerobic and anaerobic infection in patients with incomplete abortion.不全流产患者需氧菌及厌氧菌感染的发生率
S Afr Med J. 1979 Jan 27;55(4):129-32.
9
Metronidazole in anaerobic infections: a review of its activity, pharmacokinetics and therapeutic use.甲硝唑在厌氧菌感染中的应用：对其活性、药代动力学及治疗用途的综述
Drugs. 1978 Nov;16(5):387-417. doi: 10.2165/00003495-197816050-00002.
10
Concentrations of tinidazole in body fluids and tissues in gynaecological patients.妇科患者体液和组织中替硝唑的浓度。
Chemotherapy. 1977;23(4):227-35. doi: 10.1159/000221990.

单次输注后甲硝唑和替硝唑在孕早期的胎盘转运情况。

Placental transfer of metronidazole and tinidazole in early human pregnancy after a single infusion.

作者信息

Karhunen M

出版信息

Br J Clin Pharmacol. 1984 Aug;18(2):254-7. doi: 10.1111/j.1365-2125.1984.tb02465.x.

DOI:10.1111/j.1365-2125.1984.tb02465.x
PMID:6487467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1463524/
Abstract

Concentrations of metronidazole and tinidazole were analysed in mother's serum, placental tissue and foetal tissue after a single intravenous infusion of 500 mg of either drug in 21 patients who underwent a first trimester legal abortion. At the time of the evacuation (60 min from the start of the infusion) the concentrations of metronidazole and tinidazole in serum were 13.6 +/- 0.6 micrograms/ml and 13.2 +/- 0.4 micrograms/ml, respectively. In foetal tissue the concentrations of metronidazole and tinidazole reached 66% and 58%, and in placental tissue 26% and 37%, of the respective serum values.

摘要

在21例接受孕早期合法堕胎的患者中，单次静脉输注500毫克甲硝唑或替硝唑后，分析了母亲血清、胎盘组织和胎儿组织中这两种药物的浓度。在刮宫时（输注开始后60分钟），血清中甲硝唑和替硝唑的浓度分别为13.6±0.6微克/毫升和13.2±0.4微克/毫升。胎儿组织中甲硝唑和替硝唑的浓度分别达到相应血清值的66%和58%，胎盘组织中则分别为26%和37%。