单次输注后甲硝唑和替硝唑在孕早期的胎盘转运情况。
Placental transfer of metronidazole and tinidazole in early human pregnancy after a single infusion.
作者信息
Karhunen M
出版信息
Br J Clin Pharmacol. 1984 Aug;18(2):254-7. doi: 10.1111/j.1365-2125.1984.tb02465.x.
Abstract
Concentrations of metronidazole and tinidazole were analysed in mother's serum, placental tissue and foetal tissue after a single intravenous infusion of 500 mg of either drug in 21 patients who underwent a first trimester legal abortion. At the time of the evacuation (60 min from the start of the infusion) the concentrations of metronidazole and tinidazole in serum were 13.6 +/- 0.6 micrograms/ml and 13.2 +/- 0.4 micrograms/ml, respectively. In foetal tissue the concentrations of metronidazole and tinidazole reached 66% and 58%, and in placental tissue 26% and 37%, of the respective serum values.
摘要
在21例接受孕早期合法堕胎的患者中，单次静脉输注500毫克甲硝唑或替硝唑后，分析了母亲血清、胎盘组织和胎儿组织中这两种药物的浓度。在刮宫时（输注开始后60分钟），血清中甲硝唑和替硝唑的浓度分别为13.6±0.6微克/毫升和13.2±0.4微克/毫升。胎儿组织中甲硝唑和替硝唑的浓度分别达到相应血清值的66%和58%，胎盘组织中则分别为26%和37%。
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