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Effect on finger tremor of withdrawal of long-term treatment with propranolol or atenolol.普萘洛尔或阿替洛尔长期治疗停药对手指震颤的影响。
Br J Clin Pharmacol. 1984 Sep;18(3):317-24. doi: 10.1111/j.1365-2125.1984.tb02470.x.
2
Characterization of the beta-adrenoreceptors which mediate the isoprenaline-induced changes in finger tremor and cardiovascular function in man.介导异丙肾上腺素引起的人体手指震颤和心血管功能变化的β-肾上腺素能受体的特性研究。
Eur J Clin Pharmacol. 1988;35(5):507-14. doi: 10.1007/BF00558246.
3
Effect of atenolol, metoprolol, and propranolol on isoproterenol-induced tremor and tachycardia in normal subjects.阿替洛尔、美托洛尔和普萘洛尔对正常受试者异丙肾上腺素诱发的震颤和心动过速的影响。
Clin Pharmacol Ther. 1981 Apr;29(4):425-33. doi: 10.1038/clpt.1981.59.
4
Beta-adrenoceptor blockade and hypoglycaemia. A randomised, double-blind, placebo controlled comparison of metoprolol CR, atenolol and propranolol LA in normal subjects.β-肾上腺素能受体阻滞剂与低血糖症。美托洛尔控释片、阿替洛尔和普萘洛尔长效制剂在正常受试者中的随机、双盲、安慰剂对照比较。
Br J Clin Pharmacol. 1990 Jun;29(6):685-93. doi: 10.1111/j.1365-2125.1990.tb03689.x.
5
An assessment of the partial agonist activity of Ro 31-1118, flusoxolol and pindolol in man.罗 31-1118、氟索洛尔和吲哚洛尔在人体中的部分激动剂活性评估。
Br J Clin Pharmacol. 1987 Nov;24(5):571-80. doi: 10.1111/j.1365-2125.1987.tb03215.x.
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Enhancement of physiological finger tremor by intravenous isoprenaline infusions in man: evaluation of its role in the assessment of beta-adrenoceptor antagonists.静脉输注异丙肾上腺素对人体生理性手指震颤的增强作用：评估其在β-肾上腺素能受体拮抗剂评估中的作用。
Br J Clin Pharmacol. 1984 Aug;18(2):145-52. doi: 10.1111/j.1365-2125.1984.tb02446.x.
7
Withdrawal of beta-blocking drugs.β受体阻滞剂的撤药
Am Heart J. 1982 Aug;104(2 Pt 2):515-20. doi: 10.1016/0002-8703(82)90149-1.
8
The relative antihypertensive potency of propranolol, oxprenolol, atenolol, and metoprolol given once daily. A double-blind, crossover, placebo-controlled study in ambulatory patients.每日一次服用普萘洛尔、氧烯洛尔、阿替洛尔和美托洛尔的相对降压效能。一项针对非卧床患者的双盲、交叉、安慰剂对照研究。
Arch Intern Med. 1985 Jul;145(7):1321-3.
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Effects of ICI 141,292 on exercise tachycardia and isoprenaline-induced beta-adrenoceptor responses in man.ICI 141,292对人体运动性心动过速及异丙肾上腺素诱导的β-肾上腺素能受体反应的影响。
Br J Clin Pharmacol. 1986 Mar;21(3):249-58. doi: 10.1111/j.1365-2125.1986.tb05187.x.
10
Exercise-induced hand tremor: a possible test for beta 2-adrenoceptor selectivity in man?运动诱发的手部震颤：对人体β2肾上腺素能受体选择性的一种可能测试？
Br J Clin Pharmacol. 1986 Jul;22(1):104-7.

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Insights into Pathophysiology from Medication-induced Tremor.药物性震颤的病理生理学见解。
Tremor Other Hyperkinet Mov (N Y). 2017 Nov 22;7:442. doi: 10.7916/D8FJ2V9Q. eCollection 2017.
2
[How many beta-receptor blockers does the physician need?].医生需要多少种β受体阻滞剂？
Klin Wochenschr. 1987 Mar 16;65(6):289-95. doi: 10.1007/BF01773455.

本文引用的文献

1
Atenolol vs. propranolol in essential tremor. A controlled, quantitative study.阿替洛尔与普萘洛尔治疗特发性震颤的对照定量研究
Acta Neurol Scand. 1982 Nov;66(5):547-54. doi: 10.1111/j.1600-0404.1982.tb03141.x.
2
Metoprolol and propranolol in essential tremor: a double-blind, controlled study.美托洛尔与普萘洛尔治疗特发性震颤：一项双盲对照研究。
J Neurol Neurosurg Psychiatry. 1981 Sep;44(9):814-9. doi: 10.1136/jnnp.44.9.814.
3
Effects of timolol and atenolol on benign essential tremor: placebo-controlled studies based on quantitative tremor recording.噻吗洛尔和阿替洛尔对良性特发性震颤的影响：基于震颤定量记录的安慰剂对照研究。
J Neurol Neurosurg Psychiatry. 1981 Aug;44(8):677-83. doi: 10.1136/jnnp.44.8.677.
4
Randomised trial comparing propranolol with atenolol in immediate treatment of suspected myocardial infarction.在疑似心肌梗死即刻治疗中比较普萘洛尔与阿替洛尔的随机试验。
Br Med J. 1980 Mar 29;280(6218):885-8. doi: 10.1136/bmj.280.6218.885.
5
Controlled study of metoprolol and propranolol during prolonged administration in patients with essential tremor.美托洛尔与普萘洛尔对特发性震颤患者长期给药的对照研究。
J Neurol Neurosurg Psychiatry. 1982 Oct;45(10):893-7. doi: 10.1136/jnnp.45.10.893.
6
Beta-adrenoreceptor mechanisms in essential tremor; a double-blind placebo controlled trial of metoprolol, sotalol and atenolol.原发性震颤中的β-肾上腺素能受体机制；美托洛尔、索他洛尔和阿替洛尔的双盲安慰剂对照试验。
J Neurol Neurosurg Psychiatry. 1983 Aug;46(8):710-5. doi: 10.1136/jnnp.46.8.710.
7
Effect of atenolol, metoprolol, and propranolol on isoproterenol-induced tremor and tachycardia in normal subjects.阿替洛尔、美托洛尔和普萘洛尔对正常受试者异丙肾上腺素诱发的震颤和心动过速的影响。
Clin Pharmacol Ther. 1981 Apr;29(4):425-33. doi: 10.1038/clpt.1981.59.
8
An investigation of the comparative liposolubilities of beta-adrenoceptor blocking agents.β-肾上腺素能受体阻滞剂的比较脂溶性研究。
J Pharm Pharmacol. 1981 Mar;33(3):172-3. doi: 10.1111/j.2042-7158.1981.tb13743.x.
9
Beta-adrenoceptor blockers and the blood-brian barrier.β-肾上腺素能受体阻滞剂与血脑屏障
Br J Clin Pharmacol. 1981 Jun;11(6):549-53. doi: 10.1111/j.1365-2125.1981.tb01169.x.
10
Metoprolol in essential tremor.美托洛尔治疗特发性震颤
Lancet. 1980 Feb 23;1(8165):427. doi: 10.1016/s0140-6736(80)90979-4.

普萘洛尔或阿替洛尔长期治疗停药对手指震颤的影响。

Effect on finger tremor of withdrawal of long-term treatment with propranolol or atenolol.

作者信息

Wharrad H J, Birmingham A T, Wilson C G, Williams E J, Roland J M

出版信息

Br J Clin Pharmacol. 1984 Sep;18(3):317-24. doi: 10.1111/j.1365-2125.1984.tb02470.x.

DOI:10.1111/j.1365-2125.1984.tb02470.x
PMID:6487471
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1463649/
Abstract

The effect of the withdrawal of long-term beta-adrenoceptor blockade on pulse rate and finger tremor was studied in 27 patients who had been treated for 2 years following an uncomplicated myocardial infarction with either atenolol, propranolol or placebo. During treatment, pulse rate was significantly lower in patients treated with propranolol or atenolol compared with placebo. Compared with the response in the placebo group the mean increase in tremor on withdrawal of propranolol was statistically significant for postural and for work tremor in both hands. A significant increase in tremor on withdrawal of atenolol occurred only in the postural position and in a narrow frequency band (left hand, 7-11 Hz; right hand, 7-9 Hz). The differences in the effect on tremor of withdrawal of treatment with propranolol or atenolol in doses which produced similar reductions in heart rate, emphasise the beta 2 classification of peripheral receptors associated with normal muscle tremor but do not exclude the involvement of beta 1-adrenoceptors.

摘要

在27例曾患无并发症心肌梗死并接受阿替洛尔、普萘洛尔或安慰剂治疗2年的患者中，研究了长期β-肾上腺素受体阻滞剂撤药对脉搏率和手指震颤的影响。治疗期间，与安慰剂相比，接受普萘洛尔或阿替洛尔治疗的患者脉搏率显著降低。与安慰剂组相比，停用普萘洛尔后震颤的平均增加在双手的姿势性震颤和工作性震颤方面具有统计学意义。停用阿替洛尔后震颤仅在姿势位且在狭窄频段（左手7 - 11赫兹；右手7 - 9赫兹）显著增加。在产生相似心率降低的剂量下，普萘洛尔或阿替洛尔撤药对震颤影响的差异，强调了与正常肌肉震颤相关的外周受体的β₂分类，但不排除β₁ - 肾上腺素受体的参与。