年龄和性别对醋硝香豆素需求量的影响。
Effect of age and sex on acenocoumarol requirements.
作者信息
Arboix M, Laporte J R, Frati M E, Rutllan M
出版信息
Br J Clin Pharmacol. 1984 Oct;18(4):475-9. doi: 10.1111/j.1365-2125.1984.tb02494.x.
A group of 690 patients (337 males and 353 females) on long-term acenocoumarol therapy was studied. 62.8% of the values of the prothrombin ratio were within the chosen therapeutic range (1.8 to 2.7), 21.9% were below 1.8 and 15.3% were above 2.7. The daily maintenance dose, expressed on a weight basis, was found to significantly decrease with increasing age. The daily maintenance dose taken by females was significantly higher than the dose taken by males (P less than 0.05); the differences between males and females were maximal among patients aged between 21 and 50 years, and disappeared at older ages. Two hundred and twenty-eight haemorrhagic episodes in 160 patients were recorded during a total of 7797 months of follow-up. No lethal haemorrhages were observed. The overall incidence of bleeding episodes among females (3.6%) was higher than among males (2.2%) (P less than 0.001), even if menorrhagia was excluded (P less than 0.01).
对一组接受长期醋硝香豆素治疗的690例患者（337例男性和353例女性）进行了研究。凝血酶原比值的62.8%处于选定的治疗范围内（1.8至2.7），21.9%低于1.8，15.3%高于2.7。按体重计算的每日维持剂量随年龄增长而显著降低。女性服用的每日维持剂量显著高于男性（P<0.05）；男性和女性之间的差异在21至50岁的患者中最大，在老年时消失。在总共7797个月的随访期间，记录了160例患者的228次出血事件。未观察到致命性出血。女性出血事件的总体发生率（3.6%）高于男性（2.2%）（P<0.001），即使排除月经过多情况也是如此（P<0.01）。
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