西咪替丁单次给药后不改变布洛芬的药代动力学。
Cimetidine does not alter ibuprofen kinetics after a single dose.
作者信息
Conrad K A, Mayersohn M, Bliss M
出版信息
Br J Clin Pharmacol. 1984 Oct;18(4):624-6. doi: 10.1111/j.1365-2125.1984.tb02516.x.
Abstract
Cimetidine does not slow the disappearance of ibuprofen from the serum after a single dose in healthy male volunteers. This suggests that no change in ibuprofen dosing is necessary when cimetidine is co-administered.
摘要
在健康男性志愿者中，单剂量服用后，西咪替丁不会减缓布洛芬从血清中的消失速度。这表明，当与西咪替丁合用时，无需改变布洛芬的给药剂量。
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