• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

稳定单分子层囊泡的自发形成。

Spontaneous formation of stable unilamellar vesicles.

作者信息

Gabriel N E, Roberts M F

出版信息

Biochemistry. 1984 Aug 28;23(18):4011-5. doi: 10.1021/bi00313a001.

DOI:10.1021/bi00313a001
PMID:6487587
Abstract

Stable unilamellar vesicles form spontaneously upon mixing aqueous suspensions of long-chain lecithins (fatty acid chain lengths 14 carbons or longer) with small amounts (20 mol %) of micellar synthetic short-chain lecithins (fatty acid chain lengths 6-8 carbons). These vesicles are potentially ideal for any experiment (i.e., membrane protein reconstitution, drug delivery, etc.) that requires an easily formed, nonleaky unilamellar structure.

摘要

将长链卵磷脂(脂肪酸链长度为14个碳原子或更长)的水悬浮液与少量(20摩尔%)胶束状合成短链卵磷脂(脂肪酸链长度为6 - 8个碳原子)混合时,会自发形成稳定的单层囊泡。对于任何需要易于形成、无泄漏的单层结构的实验(即膜蛋白重构、药物递送等)而言,这些囊泡可能是理想之选。

相似文献

1
Spontaneous formation of stable unilamellar vesicles.稳定单分子层囊泡的自发形成。
Biochemistry. 1984 Aug 28;23(18):4011-5. doi: 10.1021/bi00313a001.
2
Interaction of short-chain lecithin with long-chain phospholipids: characterization of vesicles that form spontaneously.短链卵磷脂与长链磷脂的相互作用:对自发形成的囊泡的表征。
Biochemistry. 1986 May 20;25(10):2812-21. doi: 10.1021/bi00358a012.
3
Short-chain lecithin/long-chain phospholipid unilamellar vesicles: asymmetry, dynamics, and enzymatic hydrolysis of the short-chain component.短链卵磷脂/长链磷脂单层囊泡:短链成分的不对称性、动力学及酶促水解
Biochemistry. 1987 May 5;26(9):2432-40. doi: 10.1021/bi00383a006.
4
Spontaneous transmembrane insertion of membrane proteins into lipid vesicles facilitated by short-chain lecithins.短链卵磷脂促进膜蛋白自发跨膜插入脂质囊泡。
Biochemistry. 1986 Mar 11;25(5):1195-200. doi: 10.1021/bi00353a038.
5
Temperature-induced fusion of small unilamellar vesicles formed from saturated long-chain lecithins and diheptanoylphosphatidylcholine.温度诱导由饱和长链卵磷脂和二庚酰磷脂酰胆碱形成的小单层囊泡融合。
Biochemistry. 1989 Oct 3;28(20):8206-13. doi: 10.1021/bi00446a036.
6
Micropolarities of lipid bilayers and micelles. 5. Localization of pyrene in small unilamellar phosphatidylcholine vesicles.脂质双层和微团的微极性。5. 芘在小单层磷脂酰胆碱囊泡中的定位。
Biophys Chem. 1988 Jul 15;30(3):293-301. doi: 10.1016/0301-4622(88)85024-5.
7
Phase behaviour of mixtures of lipid X with phosphatidylcholine and phosphatidylethanolamine.脂质X与磷脂酰胆碱和磷脂酰乙醇胺混合物的相行为
Biochim Biophys Acta. 1989 Feb 27;979(2):239-50. doi: 10.1016/0005-2736(89)90440-9.
8
Acyl chain order and lateral domain formation in mixed phosphatidylcholine--sphingomyelin multilamellar and unilamellar vesicles.混合磷脂酰胆碱 - 鞘磷脂多层和单层囊泡中的酰基链有序性和侧向结构域形成
Biochemistry. 1981 Nov 24;20(24):6803-9. doi: 10.1021/bi00527a010.
9
Dynamics of the self-assembly of unilamellar vesicles.单层囊泡的自组装动力学
Phys Rev Lett. 2005 Jan 28;94(3):038303. doi: 10.1103/PhysRevLett.94.038303.
10
Mixing of oxidized and bilayer phospholipids.氧化磷脂与双层磷脂的混合。
Biochim Biophys Acta. 2015 Jul;1848(7):1472-80. doi: 10.1016/j.bbamem.2015.03.027. Epub 2015 Apr 1.

引用本文的文献

1
Formulation and Characterization of Cationic Bicelles for siRNA Delivery.用于 siRNA 递送的阳离子双分子层囊泡的制备与表征
Methods Mol Biol. 2025;2965:367-376. doi: 10.1007/978-1-0716-4742-4_18.
2
In Situ-Activated Phospholipid-Mimic Artemisinin Prodrug via Injectable Hydrogel Nano/Microsphere for Rheumatoid Arthritis Therapy.通过可注射水凝胶纳米/微球原位激活的磷脂模拟青蒿素前药用于类风湿性关节炎治疗
Research (Wash D C). 2022 Dec 15;2022:0003. doi: 10.34133/research.0003. eCollection 2022.
3
Biophysical approaches for exploring lipopeptide-lipid interactions.
生物物理方法探索脂肽-脂质相互作用。
Biochimie. 2020 Mar;170:173-202. doi: 10.1016/j.biochi.2020.01.009. Epub 2020 Jan 21.
4
Effect of Formulation Method, Lipid Composition, and PEGylation on Vesicle Lamellarity: A Small-Angle Neutron Scattering Study.制剂方法、脂质组成和聚乙二醇化对囊泡层状结构的影响:小角中子散射研究。
Langmuir. 2019 May 7;35(18):6064-6074. doi: 10.1021/acs.langmuir.8b04256. Epub 2019 Apr 12.
5
Low- q Bicelles Are Mixed Micelles.低q值双分子层囊泡是混合微团。
J Phys Chem Lett. 2018 Aug 2;9(15):4469-4473. doi: 10.1021/acs.jpclett.8b02079. Epub 2018 Jul 25.
6
Antibacterial Free Fatty Acids and Monoglycerides: Biological Activities, Experimental Testing, and Therapeutic Applications.抗菌游离脂肪酸和单甘油脂:生物学活性、实验测试和治疗应用。
Int J Mol Sci. 2018 Apr 8;19(4):1114. doi: 10.3390/ijms19041114.
7
When detergent meets bilayer: birth and coming of age of lipid bicelles.当去污剂遇上双分子层:脂质双分子微囊的诞生与发展
Prog Nucl Magn Reson Spectrosc. 2013 Feb;69:1-22. doi: 10.1016/j.pnmrs.2013.01.001. Epub 2013 Jan 23.
8
Bicelles: A natural 'molecular goniometer' for structural, dynamical and topological studies of molecules in membranes.双分子层膜泡:用于膜中分子结构、动力学和拓扑学研究的天然“分子测角仪”
Biochimie. 2009 Jun;91(6):744-51. doi: 10.1016/j.biochi.2009.02.003. Epub 2009 Feb 25.
9
Biphenyl bicelle disks align perpendicular to magnetic fields on large temperature scales: a study combining synthesis, solid-state NMR, TEM, and SAXS.联苯双分子层盘在较大温度范围内垂直于磁场排列:一项结合合成、固态核磁共振、透射电子显微镜和小角X射线散射的研究。
Biophys J. 2007 Jun 1;92(11):3949-59. doi: 10.1529/biophysj.106.097758. Epub 2007 Feb 16.
10
Effects of lipid chain length and unsaturation on bicelles stability. A phosphorus NMR study.脂链长度和不饱和度对双分子层稳定性的影响。一项磷核磁共振研究。
Biophys J. 2006 Aug 15;91(4):1357-67. doi: 10.1529/biophysj.106.085118. Epub 2006 May 26.