Gabriel N E, Roberts M F
Biochemistry. 1984 Aug 28;23(18):4011-5. doi: 10.1021/bi00313a001.
Stable unilamellar vesicles form spontaneously upon mixing aqueous suspensions of long-chain lecithins (fatty acid chain lengths 14 carbons or longer) with small amounts (20 mol %) of micellar synthetic short-chain lecithins (fatty acid chain lengths 6-8 carbons). These vesicles are potentially ideal for any experiment (i.e., membrane protein reconstitution, drug delivery, etc.) that requires an easily formed, nonleaky unilamellar structure.
将长链卵磷脂(脂肪酸链长度为14个碳原子或更长)的水悬浮液与少量(20摩尔%)胶束状合成短链卵磷脂(脂肪酸链长度为6 - 8个碳原子)混合时,会自发形成稳定的单层囊泡。对于任何需要易于形成、无泄漏的单层结构的实验(即膜蛋白重构、药物递送等)而言,这些囊泡可能是理想之选。