Baskakova G M, Kudriashov B A, Pytel' Iu A
Probl Endokrinol (Mosk). 1981 Jul-Aug;27(4):42-5.
Hyperglycemia, induced by the disorder of Langerhans' islet structure and function, and hyperuricemia caused by purine metabolism pathological changes, appeared in the animals with experimental diabetes provoked by a single alloxan injection. As a result, endogenous alloxan-like factor, forming chronic diabetogenic background in the organism, arises and persists in the blood of the animals tested. Under these conditions, heparin exerts preventive and therapeutic effects due to alloxan or endogenous alloxan-like factor binding into complexes devoid of toxic activity.
单次注射四氧嘧啶诱发实验性糖尿病的动物出现了由胰岛结构和功能紊乱引起的高血糖症，以及由嘌呤代谢病理变化导致的高尿酸血症。结果，内源性四氧嘧啶样因子在动物体内形成慢性致糖尿病背景，并在受试动物血液中产生并持续存在。在这些情况下，肝素通过与四氧嘧啶或内源性四氧嘧啶样因子结合形成无毒性活性的复合物而发挥预防和治疗作用。
