Boakes A J, Loo P S, Ridgway G L, Tovey S, Oriel J D
Br J Vener Dis. 1984 Oct;60(5):309-11. doi: 10.1136/sti.60.5.309.
One hundred women with uncomplicated gonorrhoea (in five cases due to penicillinase producing strains of Neisseria gonorrhoeae (PPNG)) were treated with a single oral dose of rifampicin 900 mg and erythromycin stearate 1 g. N gonorrhoeae was reisolated from the oropharynx of one patient, who was infected with a PPNG strain, but was eradicated from the genital tract in 100% of cases. The combination eradicated Chlamydia trachomatis from only 10 (28%) of the 36 patients infected. Side effects were predominantly mild and consisted of transient nausea. The treatment merits evaluation in areas with a high incidence of PPNG strains.
100例单纯性淋病患者(其中5例由产青霉素酶的淋病奈瑟菌(PPNG)引起)接受了单次口服900mg利福平及1g硬脂酸红霉素的治疗。从1例感染PPNG菌株的患者口咽部再次分离出淋病奈瑟菌,但100%的病例中该菌已从生殖道清除。该联合用药仅使36例受感染患者中的10例(28%)清除了沙眼衣原体。副作用主要为轻度,包括短暂的恶心。在PPNG菌株高发地区,该治疗值得评估。