用利福平与红霉素联合治疗女性单纯性淋病。
Treatment of uncomplicated gonorrhoea in women with a combination of rifampicin and erythromycin.
作者信息
Boakes A J, Loo P S, Ridgway G L, Tovey S, Oriel J D
出版信息
Br J Vener Dis. 1984 Oct;60(5):309-11. doi: 10.1136/sti.60.5.309.
Abstract
One hundred women with uncomplicated gonorrhoea (in five cases due to penicillinase producing strains of Neisseria gonorrhoeae (PPNG)) were treated with a single oral dose of rifampicin 900 mg and erythromycin stearate 1 g. N gonorrhoeae was reisolated from the oropharynx of one patient, who was infected with a PPNG strain, but was eradicated from the genital tract in 100% of cases. The combination eradicated Chlamydia trachomatis from only 10 (28%) of the 36 patients infected. Side effects were predominantly mild and consisted of transient nausea. The treatment merits evaluation in areas with a high incidence of PPNG strains.
摘要
100例单纯性淋病患者（其中5例由产青霉素酶的淋病奈瑟菌（PPNG）引起）接受了单次口服900mg利福平及1g硬脂酸红霉素的治疗。从1例感染PPNG菌株的患者口咽部再次分离出淋病奈瑟菌，但100%的病例中该菌已从生殖道清除。该联合用药仅使36例受感染患者中的10例（28%）清除了沙眼衣原体。副作用主要为轻度，包括短暂的恶心。在PPNG菌株高发地区，该治疗值得评估。
相似文献
1
Treatment of uncomplicated gonorrhoea in women with a combination of rifampicin and erythromycin.用利福平与红霉素联合治疗女性单纯性淋病。
Br J Vener Dis. 1984 Oct;60(5):309-11. doi: 10.1136/sti.60.5.309.
2
Treatment of gonococcal urethritis in men with a rifampicin-erythromycin combination.利福平与红霉素联合治疗男性淋菌性尿道炎
Sex Transm Dis. 1982 Oct-Dec;9(4):208-11. doi: 10.1097/00007435-198210000-00011.
3
Rifampicin-erythromycin combination for the treatment of gonococcal urethritis in men.利福平-红霉素联合用药治疗男性淋菌性尿道炎
Southeast Asian J Trop Med Public Health. 1984 Sep;15(3):360-3.
4
Single dose cefoxitin in treating uncomplicated gonorrhoea caused by penicillinase producing Neisseria gonorrhoeae (PPNG) and non-PPNG strains.单剂量头孢西丁治疗由产青霉素酶淋病奈瑟菌（PPNG）和非PPNG菌株引起的无并发症淋病。
Genitourin Med. 1986 Aug;62(4):224-7. doi: 10.1136/sti.62.4.224.
5
The combination of rifampicin-erythromycin in the treatment of gonococcal urethritis in men.利福平-红霉素联合治疗男性淋菌性尿道炎
J Med Assoc Thai. 1985 Nov;68(11):579-82.
6
[New recommendations in the treatment of genital infections caused by Neisseria gonorrhoeae in Puerto Rico].[波多黎各淋病奈瑟菌引起的生殖器感染治疗新建议]
Bol Asoc Med P R. 1985 Aug;77(8):343-4.
7
Open study of the safety and efficacy of a single oral dose of azithromycin for the treatment of uncomplicated gonorrhoea in men and women.单剂量口服阿奇霉素治疗男性和女性单纯性淋病的安全性和有效性开放性研究。
J Antimicrob Chemother. 1993 Jun;31 Suppl E:193-8. doi: 10.1093/jac/31.suppl_e.193.
8
9
Hyperendemic penicillinase-producing Neisseria gonorrhoeae genital infections in an inner city population.市中心城区人群中高度流行的产青霉素酶淋病奈瑟菌引起的生殖器感染
J Adolesc Health. 1995 Jan;16(1):41-4. doi: 10.1016/1054-139X(94)00042-D.
10
Azithromycin in the treatment of sexually transmitted disease.
J Antimicrob Chemother. 1990 Jan;25 Suppl A:109-14. doi: 10.1093/jac/25.suppl_a.109.
引用本文的文献
1
Rifampicin Resistance Associated with Mutations in Neisseria gonorrhoeae Clinical Strains Isolated in Austria, 2016 to 2020.2016 年至 2020 年奥地利分离的淋病奈瑟菌临床株中与利福平耐药相关的突变。
Microbiol Spectr. 2022 Jun 29;10(3):e0275721. doi: 10.1128/spectrum.02757-21. Epub 2022 Jun 9.
2
In vitro synergy testing of novel antimicrobial combination therapies against Neisseria gonorrhoeae.新型抗菌联合疗法针对淋病奈瑟菌的体外协同试验
J Antimicrob Chemother. 2014 Jun;69(6):1572-8. doi: 10.1093/jac/dkt540. Epub 2014 Jan 26.
3
Antimicrobial susceptibility testing of Neisseria gonorrhoeae and implications for epidemiology and therapy.淋病奈瑟菌的药敏试验及其对流行病学和治疗的意义。
Clin Microbiol Rev. 1993 Jan;6(1):22-33. doi: 10.1128/CMR.6.1.22.
4
Use of rifampin in nonstaphylococcal, nonmycobacterial disease.利福平在非葡萄球菌、非分枝杆菌疾病中的应用。
Antimicrob Agents Chemother. 1993 Jan;37(1):1-7. doi: 10.1128/AAC.37.1.1.
本文引用的文献
1
Treatment of gonococcal urethritis in men with a rifampicin-erythromycin combination.利福平与红霉素联合治疗男性淋菌性尿道炎
Sex Transm Dis. 1982 Oct-Dec;9(4):208-11. doi: 10.1097/00007435-198210000-00011.
2
Penicillinase-producing Neisseria gonorrhoeae.
N Engl J Med. 1982 Dec 30;307(27):1706. doi: 10.1056/NEJM198212303072712.
3
Penicillinase-producing Neisseria gonorrhoeae in Great Britain, 1977-81: alarming increase in incidence and recent development of endemic transmission.1977 - 1981年英国产青霉素酶淋病奈瑟菌：发病率惊人上升及近期地方性传播的发展情况
Br Med J (Clin Res Ed). 1982 Jul 31;285(6338):337-40. doi: 10.1136/bmj.285.6338.337.
4
Evidence that rifampicin can be used safely for non-tuberculous diseases.利福平可安全用于非结核疾病的证据。
Thorax. 1980 Oct;35(10):788-91. doi: 10.1136/thx.35.10.788.
5
Treatment of gonorrhoea with single oral doses of rifampicin.单次口服利福平治疗淋病
Br Med J. 1968 Dec 14;4(5632):681-2. doi: 10.1136/bmj.4.5632.681.
6
Rifampicin compared with penicllin in the treatment of gonorrhea.利福平与青霉素治疗淋病的比较。
Chemotherapy. 1971;16(5):319-25. doi: 10.1159/000220742.
7
Comparison of erythromycin stearate and oxytetracycline in the treatment of non-gonococcal urethritis: their efficacy against Chlamydia trachomatis.
Scott Med J. 1977 Dec;22(5):375-9. doi: 10.1177/00369330770220S106.
8
Comparison of erythromycin base and estolate in gonococcal urethritis.红霉素碱与无味红霉素治疗淋菌性尿道炎的比较。
JAMA. 1977 Sep 26;238(13):1371-3.
9
Penicillinase-producing Neisseria gonorrhoeae.产青霉素酶淋病奈瑟菌
Lancet. 1976 Oct 9;2(7989):793.
Zotero 插件