单剂量头孢西丁治疗由产青霉素酶淋病奈瑟菌（PPNG）和非PPNG菌株引起的无并发症淋病。
Single dose cefoxitin in treating uncomplicated gonorrhoea caused by penicillinase producing Neisseria gonorrhoeae (PPNG) and non-PPNG strains.
作者信息
Lim K B, Thirumoorthy T, Lee C T, Tham S N, Sng E H, Tan T
出版信息
Genitourin Med. 1986 Aug;62(4):224-7. doi: 10.1136/sti.62.4.224.
A total of 136 patients with uncomplicated gonorrhoea were treated with intramuscular cefoxitin 2 g (25 patients) or 1 g (111 patients) and oral probenecid 1 g. Cefoxitin 1 g cured 95% (42 out of 45 men and all of 14 women) with infections caused by penicillinase producing Neisseria gonorrhoeae (PPNG) strains and 98% (all of 38 men and 13 out of 14 women) with non-PPNG infections, giving an overall cure rate of 96%. The rate of postgonococcal urethritis (PGU) in men treated with 1 g cefoxitin was 28%. No serious side effects of treatment were observed in patients treated with either dose. The failure rate of 7% in men infected with PPNG strains who were treated with the 1 g dose is, however, disturbing. We therefore recommend that intramuscular cefoxitin 2 g and oral probenecid 1 g may be used to treat uncomplicated gonorrhoea, especially in areas where PPNG strains are common.
总共136例单纯性淋病患者接受了治疗，其中25例患者肌肉注射头孢西丁2g，111例患者肌肉注射头孢西丁1g并口服丙磺舒1g。头孢西丁1g治愈了95%（45名男性中的42名以及14名女性中的全部）由产青霉素酶淋病奈瑟菌（PPNG）菌株引起的感染，以及98%（38名男性中的全部以及14名女性中的13名）非PPNG感染，总体治愈率为96%。接受1g头孢西丁治疗的男性中，淋菌性尿道炎（PGU）的发生率为28%。两种剂量治疗的患者均未观察到严重的治疗副作用。然而，接受1g剂量治疗的感染PPNG菌株的男性中7%的失败率令人不安。因此，我们建议肌肉注射头孢西丁2g并口服丙磺舒1g可用于治疗单纯性淋病，尤其是在PPNG菌株常见的地区。
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