Waksvik H, Boysen M, Høgetveit A C
Carcinogenesis. 1984 Nov;5(11):1525-7. doi: 10.1093/carcin/5.11.1525.
Chromosomal aberrations and sister chromatid exchanges were analysed in the peripheral lymphocytes of nine retired nickel refinery workers 4-15 years after the retirement and compared with 11 matched non-nickel exposed controls. None of the controls had previous occupations with known relation to induction of chromosomal aberrations nor sister chromatid exchanges. The groups were equal as to socioeconomic status and environmental factors other than the occupational ones, which could influence the chromosome parameters, were to the largest possible extent excluded. The nickel workers' previous occupational employment involved exposure to inhalation of furnace dust of Ni3S2 and NiO or aerosols of NiCl2 and NiSO4. The concentration of nickel in the working atmospheres has been higher than 1.0 mg/m3 air and the exposure time more than 25 years. The retired nickel workers showed an increased incidence of breaks (p less than 0.001) and gaps (p less than 0.05) but no difference in the incidence of sister chromatid exchanges when compared with the controls.
对9名退休镍精炼厂工人退休4至15年后外周血淋巴细胞的染色体畸变和姐妹染色单体交换进行了分析，并与11名匹配的未接触镍的对照组进行了比较。对照组中没有人从事过与诱导染色体畸变或姐妹染色单体交换有已知关联的职业。两组在社会经济地位方面相当，并且尽可能排除了除职业因素之外可能影响染色体参数的环境因素。镍厂工人以前的职业接触包括吸入Ni3S2和NiO的炉尘或NiCl2和NiSO4的气溶胶。工作环境中的镍浓度高于1.0毫克/立方米空气，接触时间超过25年。与对照组相比，退休镍厂工人的断裂发生率（p<0.001）和裂隙发生率（p<0.05）有所增加，但姐妹染色单体交换发生率没有差异。
